BCL10

B-cell CLL/lymphoma 10, also known as BCL10, is a human gene.cite web | title = Entrez Gene: BCL10 B-cell CLL/lymphoma 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8915| accessdate = ]

PBB_Summary
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summary_text = This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.cite web | title = Entrez Gene: BCL10 B-cell CLL/lymphoma 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8915| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bertoni F, Cavalli F, Cotter FE, Zucca E |title=Genetic alterations underlying the pathogenesis of MALT lymphoma. |journal=Hematol. J. |volume=3 |issue= 1 |pages= 10–3 |year= 2003 |pmid= 11960389 |doi= 10.1038/sj/thj/6200146
*cite journal | author=Lee WC, Balsara B, Liu Z, "et al." |title=Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma. |journal=Cancer Res. |volume=56 |issue= 19 |pages= 4297–301 |year= 1996 |pmid= 8813110 |doi=
*cite journal | author=Willis TG, Jadayel DM, Du MQ, "et al." |title=Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. |journal=Cell |volume=96 |issue= 1 |pages= 35–45 |year= 1999 |pmid= 9989495 |doi=
*cite journal | author=Koseki T, Inohara N, Chen S, "et al." |title=CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 9955–61 |year= 1999 |pmid= 10187770 |doi=
*cite journal | author=Thome M, Martinon F, Hofmann K, "et al." |title=Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 9962–8 |year= 1999 |pmid= 10187771 |doi=
*cite journal | author=Yan M, Lee J, Schilbach S, "et al." |title=mE10, a novel caspase recruitment domain-containing proapoptotic molecule. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10287–92 |year= 1999 |pmid= 10187815 |doi=
*cite journal | author=Zhang Q, Siebert R, Yan M, "et al." |title=Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). |journal=Nat. Genet. |volume=22 |issue= 1 |pages= 63–8 |year= 1999 |pmid= 10319863 |doi= 10.1038/8767
*cite journal | author=Srinivasula SM, Ahmad M, Lin JH, "et al." |title=CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17946–54 |year= 1999 |pmid= 10364242 |doi=
*cite journal | author=Apostolou S, De Rienzo A, Murthy SS, "et al." |title=Absence of BCL10 mutations in human malignant mesothelioma. |journal=Cell |volume=97 |issue= 6 |pages= 684–6; discussion 686–8 |year= 1999 |pmid= 10380921 |doi=
*cite journal | author=Costanzo A, Guiet C, Vito P |title=c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20127–32 |year= 1999 |pmid= 10400625 |doi=
*cite journal | author=Yoneda T, Imaizumi K, Maeda M, "et al." |title=Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11114–20 |year= 2000 |pmid= 10753917 |doi=
*cite journal | author=Ye H, Dogan A, Karran L, "et al." |title=BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. |journal=Am. J. Pathol. |volume=157 |issue= 4 |pages= 1147–54 |year= 2000 |pmid= 11021819 |doi=
*cite journal | author=Bertin J, Guo Y, Wang L, "et al." |title=CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. |journal=J. Biol. Chem. |volume=275 |issue= 52 |pages= 41082–6 |year= 2001 |pmid= 11053425 |doi= 10.1074/jbc.C000726200
*cite journal | author=Uren AG, O'Rourke K, Aravind LA, "et al." |title=Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. |journal=Mol. Cell |volume=6 |issue= 4 |pages= 961–7 |year= 2000 |pmid= 11090634 |doi=
*cite journal | author=Poyet JL, Srinivasula SM, Alnemri ES |title=vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 3183–7 |year= 2001 |pmid= 11113112 |doi= 10.1074/jbc.C000792200
*cite journal | author=Ruland J, Duncan GS, Elia A, "et al." |title=Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. |journal=Cell |volume=104 |issue= 1 |pages= 33–42 |year= 2001 |pmid= 11163238 |doi=
*cite journal | author=Wang L, Guo Y, Huang WJ, "et al." |title=Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21405–9 |year= 2001 |pmid= 11259443 |doi= 10.1074/jbc.M102488200
*cite journal | author=Lucas PC, Yonezumi M, Inohara N, "et al." |title=Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19012–9 |year= 2001 |pmid= 11262391 |doi= 10.1074/jbc.M009984200
*cite journal | author=Bertin J, Wang L, Guo Y, "et al." |title=CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 11877–82 |year= 2001 |pmid= 11278692 |doi= 10.1074/jbc.M010512200
*cite journal | author=Gaide O, Martinon F, Micheau O, "et al." |title=Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. |journal=FEBS Lett. |volume=496 |issue= 2-3 |pages= 121–7 |year= 2001 |pmid= 11356195 |doi=

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