CARD11

Caspase recruitment domain family, member 11, also known as CARD11, is a human gene.cite web | title = Entrez Gene: CARD11 caspase recruitment domain family, member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84433| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.cite web | title = Entrez Gene: CARD11 caspase recruitment domain family, member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84433| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Wang L, Guo Y, Huang WJ, "et al." |title=Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21405–9 |year= 2001 |pmid= 11259443 |doi= 10.1074/jbc.M102488200
*cite journal | author=Bertin J, Wang L, Guo Y, "et al." |title=CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 11877–82 |year= 2001 |pmid= 11278692 |doi= 10.1074/jbc.M010512200
*cite journal | author=Gaide O, Martinon F, Micheau O, "et al." |title=Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. |journal=FEBS Lett. |volume=496 |issue= 2-3 |pages= 121–7 |year= 2001 |pmid= 11356195 |doi=
*cite journal | author=Wang D, You Y, Case SM, "et al." |title=A requirement for CARMA1 in TCR-induced NF-kappa B activation. |journal=Nat. Immunol. |volume=3 |issue= 9 |pages= 830–5 |year= 2002 |pmid= 12154356 |doi= 10.1038/ni824
*cite journal | author=Gaide O, Favier B, Legler DF, "et al." |title=CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. |journal=Nat. Immunol. |volume=3 |issue= 9 |pages= 836–43 |year= 2002 |pmid= 12154360 |doi= 10.1038/ni830
*cite journal | author=Pomerantz JL, Denny EM, Baltimore D |title=CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. |journal=EMBO J. |volume=21 |issue= 19 |pages= 5184–94 |year= 2002 |pmid= 12356734 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Wang D, Matsumoto R, You Y, "et al." |title=CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. |journal=Mol. Cell. Biol. |volume=24 |issue= 1 |pages= 164–71 |year= 2004 |pmid= 14673152 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Stilo R, Liguoro D, Di Jeso B, "et al." |title=Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator. |journal=J. Biol. Chem. |volume=279 |issue= 33 |pages= 34323–31 |year= 2004 |pmid= 15184390 |doi= 10.1074/jbc.M402244200
*cite journal | author=Lee KY, D'Acquisto F, Hayden MS, "et al." |title=PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. |journal=Science |volume=308 |issue= 5718 |pages= 114–8 |year= 2005 |pmid= 15802604 |doi= 10.1126/science.1107107
*cite journal | author=Shinohara H, Yasuda T, Aiba Y, "et al." |title=PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. |journal=J. Exp. Med. |volume=202 |issue= 10 |pages= 1423–31 |year= 2006 |pmid= 16301747 |doi= 10.1084/jem.20051591
*cite journal | author=Sommer K, Guo B, Pomerantz JL, "et al." |title=Phosphorylation of the CARMA1 linker controls NF-kappaB activation. |journal=Immunity |volume=23 |issue= 6 |pages= 561–74 |year= 2006 |pmid= 16356855 |doi= 10.1016/j.immuni.2005.09.014
*cite journal | author=Matsumoto R, Wang D, Blonska M, "et al." |title=Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. |journal=Immunity |volume=23 |issue= 6 |pages= 575–85 |year= 2006 |pmid= 16356856 |doi= 10.1016/j.immuni.2005.10.007
*cite journal | author=Narayan P, Holt B, Tosti R, Kane LP |title=CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. |journal=Mol. Cell. Biol. |volume=26 |issue= 6 |pages= 2327–36 |year= 2006 |pmid= 16508008 |doi= 10.1128/MCB.26.6.2327-2336.2006
*cite journal | author=Ishiguro K, Avruch J, Landry A, "et al." |title=Nore1B regulates TCR signaling via Ras and Carma1. |journal=Cell. Signal. |volume=18 |issue= 10 |pages= 1647–54 |year= 2006 |pmid= 16520020 |doi= 10.1016/j.cellsig.2006.01.015
*cite journal | author=Ishiguro K, Green T, Rapley J, "et al." |title=Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation. |journal=Mol. Cell. Biol. |volume=26 |issue= 14 |pages= 5497–508 |year= 2006 |pmid= 16809782 |doi= 10.1128/MCB.02469-05

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