PIAS1

PIAS1

Protein inhibitor of activated STAT, 1, also known as PIAS1, is a human gene.cite web | title = Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8554| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.cite web | title = Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8554| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Valdez BC, Henning D, Perlaky L, "et al." |title=Cloning and characterization of Gu/RH-II binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=234 |issue= 2 |pages= 335–40 |year= 1997 |pmid= 9177271 |doi= 10.1006/bbrc.1997.6642
*cite journal | author=Liu B, Liao J, Rao X, "et al." |title=Inhibition of Stat1-mediated gene activation by PIAS1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 18 |pages= 10626–31 |year= 1998 |pmid= 9724754 |doi=
*cite journal | author=Tan J, Hall SH, Hamil KG, "et al." |title=Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis. |journal=Mol. Endocrinol. |volume=14 |issue= 1 |pages= 14–26 |year= 2000 |pmid= 10628744 |doi=
*cite journal | author=Liao J, Fu Y, Shuai K |title=Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 10 |pages= 5267–72 |year= 2000 |pmid= 10805787 |doi=
*cite journal | author=Kotaja N, Aittomäki S, Silvennoinen O, "et al." |title=ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation. |journal=Mol. Endocrinol. |volume=14 |issue= 12 |pages= 1986–2000 |year= 2001 |pmid= 11117529 |doi=
*cite journal | author=Gross M, Liu B, Tan J, "et al." |title=Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells. |journal=Oncogene |volume=20 |issue= 29 |pages= 3880–7 |year= 2001 |pmid= 11439351 |doi= 10.1038/sj.onc.1204489
*cite journal | author=Liu B, Shuai K |title=Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36624–31 |year= 2001 |pmid= 11451946 |doi= 10.1074/jbc.M101085200
*cite journal | author=Kahyo T, Nishida T, Yasuda H |title=Involvement of PIAS1 in the sumoylation of tumor suppressor p53. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 713–8 |year= 2001 |pmid= 11583632 |doi=
*cite journal | author=Weiskirchen R, Moser M, Weiskirchen S, "et al." |title=LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. |journal=Biochem. J. |volume=359 |issue= Pt 3 |pages= 485–96 |year= 2001 |pmid= 11672422 |doi=
*cite journal | author=Megidish T, Xu JH, Xu CW |title=Activation of p53 by protein inhibitor of activated Stat1 (PIAS1). |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8255–9 |year= 2002 |pmid= 11788578 |doi= 10.1074/jbc.C200001200
*cite journal | author=Schmidt D, Müller S |title=Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2872–7 |year= 2002 |pmid= 11867732 |doi= 10.1073/pnas.052559499
*cite journal | author=Tan JA, Hall SH, Hamil KG, "et al." |title=Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16993–7001 |year= 2002 |pmid= 11877418 |doi= 10.1074/jbc.M109217200
*cite journal | author=Nishida T, Yasuda H |title=PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 41311–7 |year= 2003 |pmid= 12177000 |doi= 10.1074/jbc.M206741200
*cite journal | author=Rui HL, Fan E, Zhou HM, "et al." |title=SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42981–6 |year= 2003 |pmid= 12223491 |doi= 10.1074/jbc.M208099200
*cite journal | author=Sapetschnig A, Rischitor G, Braun H, "et al." |title=Transcription factor Sp3 is silenced through SUMO modification by PIAS1. |journal=EMBO J. |volume=21 |issue= 19 |pages= 5206–15 |year= 2002 |pmid= 12356736 |doi=
*cite journal | author=Miyauchi Y, Yogosawa S, Honda R, "et al." |title=Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 50131–6 |year= 2003 |pmid= 12393906 |doi= 10.1074/jbc.M208319200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ungureanu D, Vanhatupa S, Kotaja N, "et al." |title=PIAS proteins promote SUMO-1 conjugation to STAT1. |journal=Blood |volume=102 |issue= 9 |pages= 3311–3 |year= 2004 |pmid= 12855578 |doi= 10.1182/blood-2002-12-3816
*cite journal | author=Kadaré G, Toutant M, Formstecher E, "et al." |title=PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 47434–40 |year= 2004 |pmid= 14500712 |doi= 10.1074/jbc.M308562200
*cite journal | author=Tallec LP, Kirsh O, Lecomte MC, "et al." |title=Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification. |journal=Mol. Endocrinol. |volume=17 |issue= 12 |pages= 2529–42 |year= 2004 |pmid= 14500761 |doi= 10.1210/me.2003-0299

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