CARD9

Caspase recruitment domain family, member 9, also known as CARD9, is a human gene.cite web | title = Entrez Gene: CARD9 caspase recruitment domain family, member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64170| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined.cite web | title = Entrez Gene: CARD9 caspase recruitment domain family, member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64170| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yang H, Minamishima YA, Yan Q, "et al." |title=pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2. |journal=Mol. Cell |volume=28 |issue= 1 |pages= 15-27 |year= 2008 |pmid= 17936701 |doi= 10.1016/j.molcel.2007.09.010
*cite journal | author=Hsu YM, Zhang Y, You Y, "et al." |title=The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. |journal=Nat. Immunol. |volume=8 |issue= 2 |pages= 198-205 |year= 2007 |pmid= 17187069 |doi= 10.1038/ni1426
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Humphray SJ, Oliver K, Hunt AR, "et al." |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang L, Guo Y, Huang WJ, "et al." |title=Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21405-9 |year= 2001 |pmid= 11259443 |doi= 10.1074/jbc.M102488200
*cite journal | author=Bertin J, Guo Y, Wang L, "et al." |title=CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. |journal=J. Biol. Chem. |volume=275 |issue= 52 |pages= 41082-6 |year= 2001 |pmid= 11053425 |doi= 10.1074/jbc.C000726200

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