Pyrimidine-nucleoside phosphorylase
- Pyrimidine-nucleoside phosphorylase
In enzymology, a pyrimidine-nucleoside phosphorylase (EC number|2.4.2.2) is an enzyme that catalyzes the chemical reaction
:a pyrimidine nucleoside + phosphate a pyrimidine base + alpha-D-ribose 1-phosphate
Thus, the two substrates of this enzyme are pyrimidine nucleoside and phosphate, whereas its two products are pyrimidine base and alpha-D-ribose 1-phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase. This enzyme is also called Py-NPase. This enzyme participates in pyrimidine metabolism.
tructural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BRW and PDB link|2DSJ.
References
* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 237-255.
*
*
External links
::"The CAS registry number for this enzyme class is CAS registry|9055-35-0."
Gene Ontology (GO) codes
Wikimedia Foundation.
2010.
Look at other dictionaries:
pyrimidine-nucleoside phosphorylase — py·rim·i·dine nu·cleo·side phos·phor·y·lase (pə rimґĭ dēn nooґkle o sīd″ fos forґə lās) [EC 2.4.2.2] an enzyme of the transferase class that catalyzes the cleavage of pyrimidine nucleosides to form pyrimidines… … Medical dictionary
nucleoside phosphorylase — n NUCLEOSIDASE (2) * * * nu·cleo·side phos·phor·y·lase (nooґkle o sīd″ fos forґə lās) any of the enzymes of the sub subclass pentosyltransferases [EC 2.4.2] that catalyze the phosphorolysis of a nucleoside to form the free… … Medical dictionary
Purine nucleoside phosphorylase — Not to be confused with polynucleotide phosphorylase. purine nucleoside phosphorylase Identifiers EC number 2.4.2.1 CAS number … Wikipedia
Purine-nucleoside phosphorylase — In enzymology, a purine nucleoside phosphorylase (EC number|2.4.2.1) is an enzyme that catalyzes the chemical reaction:purine nucleoside + phosphate ightleftharpoons purine + alpha D ribose 1 phosphateThus, the two substrates of this enzyme are… … Wikipedia
Nucleoside-diphosphate kinase — Nucleoside diphosphate kinases (NDKs, also NDP Kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes that catalyze the exchange of phosphate groups between different nucleoside diphosphates. NDK activities maintain an… … Wikipedia
List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… … Wikipedia
Deoxycytidine kinase — PDB rendering based on 1p5z … Wikipedia
Nucleotide salvage — A salvage pathway is a pathway in which nucleotides (purine and pyrimidine) are synthesized from intermediates in the degradative pathway for nucleotides. Salvage pathways are used to recover bases and nucleosides that are formed during… … Wikipedia
Metabolism — Cell metabolism redirects here. For the journal, see Cell Metabolism. Structure of adenosine triphosphate, a central intermediate in energy metabolism Metabolism (from Greek: μεταβολή metabolē , change or Greek: μεταβολισμός metabolismos,… … Wikipedia
Uridine monophosphate synthetase — PDB rendering based on 2eaw … Wikipedia
