O-acetylhomoserine aminocarboxypropyltransferase

O-acetylhomoserine aminocarboxypropyltransferase
O-acetylhomoserine aminocarboxypropyltransferase
Identifiers
EC number 2.5.1.49
CAS number 37290-90-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) is an enzyme that catalyzes the chemical reaction

O-acetyl-L-homoserine + methanethiol \rightleftharpoons L-methionine + acetate

Thus, the two substrates of this enzyme are O-acetyl-L-homoserine and methanethiol, whereas its two products are L-methionine and acetate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase. Other names in common use include O-acetyl-L-homoserine acetate-lyase (adding methanethiol), O-acetyl-L-homoserine sulfhydrolase, O-acetylhomoserine (thiol)-lyase, O-acetylhomoserine sulfhydrolase, and methionine synthase. This enzyme participates in methionine metabolism and cysteine metabolism.

References

  • Kerr D (1971). "O-Acetylhomoserine sulfhydrylase (Neurospora)". Methods Enzymol. 17B: 446–450. 
  • Smith IK, Thompson JF (1969). "Utilization of S-methylcysteine and methylmercaptan by methionineless mutants of Neurospora and the pathway of their conversion to methionine. II. Enzyme studies". Biochim. Biophys. Acta. 184 (1): 130–8. PMID 5791104. 
  • Yamagata S, Takeshima K (Tokyo). "O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast Further purification and characterization as a pyridoxal enzyme". J. Biochem. (4): 777–85. PMID 795806. 
  • Yamagata S (Tokyo). "O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast Subunit structure". J. Biochem. (4): 787–97. PMID 795807. 
  • Yamagata S, Takeshima K, Naiki N (Tokyo). "Evidence for the identity of O-acetylserine sulfhydrylase with O-acetylhomoserine sulfhydrylase in yeast". J. Biochem. (6): 1221–9. PMID 4609980. 
  • Yamagata S (1989). "Roles of O-acetyl-L-homoserine sulfhydrylases in micro-organisms". Biochimie. 71 (11–12): 1125–43. PMID 2517474. 
  • Kuramitsu S, Iwama T (2001). "Cloning and overexpression of the oah1 gene encoding O-acetyl-L-homoserine sulfhydrylase of Thermus thermophilus HB8 and characterization of the gene product". Biochim. Biophys. Acta. 1549 (1): 61–72. doi:10.1016/S0167-4838(01)00245-X. PMID 11566369. 
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