- O-phosphoserine sulfhydrylase
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O-phosphoserine sulfhydrylase Identifiers EC number 2.5.1.65 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Search PMC articles PubMed articles In enzymology, an O-phosphoserine sulfhydrylase (EC 2.5.1.65) is an enzyme that catalyzes the chemical reaction
- O-phospho-L-serine + hydrogen sulfide
L-cysteine + phosphate
Thus, the two substrates of this enzyme are O-phospho-L-serine and hydrogen sulfide, whereas its two products are L-cysteine and phosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase. This enzyme is also called O-phosphoserine(thiol)-lyase. This enzyme participates in cysteine metabolism and sulfur metabolism.
References
- Mino K, Ishikawa K (2003). "A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1". FEBS Lett. 551 (1–3): 133–8. doi:10.1016/S0014-5793(03)00913-X. PMID 12965218.
- Mino K, Ishikawa K (2003). "Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1". J. Bacteriol. 185 (7): 2277–84. doi:10.1128/JB.185.7.2277-2284.2003. PMC 151494. PMID 12644499. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151494.
- Mino K, Oda Y, Ataka M, Ishikawa K (2003). "Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1". Acta Crystallogr. D 59 (Pt 2): 338–40. doi:10.1107/S0907444902017900. PMID 12554945.
This transferase article is a stub. You can help Wikipedia by expanding it. - O-phospho-L-serine + hydrogen sulfide
