Fatty-acyl-CoA synthase

Fatty-acyl-CoA synthase

In enzymology, a fatty-acyl-CoA synthase (EC number| is an enzyme that catalyzes the chemical reaction

:acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ ightleftharpoons long-chain-acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+

The 3 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADH, NADPH, and H+, whereas its 5 products are long-chain-acyl-CoA, CoA, CO2, NAD+, and NADP+.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing). This enzyme is also called yeast fatty acid synthase. This enzyme participates in fatty acid biosynthesis.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2PFF and PDB link|2UV8.



ee also

Long fatty acyl-CoA syntetase

External links

::"The CAS registry number for this enzyme class is CAS registry|9045-77-6."

Gene Ontology (GO) codes

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