Fatty-acid synthase

In enzymology, a fatty-acid synthase (EC number|2.3.1.85) is an enzyme that catalyzes the chemical reaction

:acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H⁺ $ightleftharpoons$ a long-chain fatty acid + (n⁺1) CoA + n CO₂ + 2n NADP⁺

The 4 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, and H⁺, whereas its 4 products are long-chain fatty acid, CoA, CO₂, and NADP⁺.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing). This enzyme is also called yeast fatty acid synthase. This enzyme participates in fatty acid biosynthesis and insulin signaling pathway.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1N8L, PDB link|2CF2, PDB link|2CG5, PDB link|2JFD, PDB link|2JFK, PDB link|2PNG, and PDB link|2PX6.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9045-77-6."

Gene Ontology (GO) codes