Erythronolide synthase

In enzymology, an erythronolide synthase (EC number|2.3.1.94) is an enzyme that catalyzes the chemical reaction

:6 malonyl-CoA + propanoyl-CoA $ightleftharpoons$ 7 CoA + 6-deoxyerythronolide b

Thus, the two substrates of this enzyme are malonyl-CoA and propanoyl-CoA, whereas its two products are CoA and 6-deoxyerythronolide b.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:propanoyl-CoA malonyltransferase (cyclizing). Other names in common use include erythronolide condensing enzyme, and malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing). This enzyme participates in biosynthesis of 12-, 14- and 16-membered macrolides.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1KEZ, PDB link|1MO2, PDB link|1PZQ, PDB link|1PZR, PDB link|2HG4, PDB link|2JU1, PDB link|2JU2, and PDB link|2QO3.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|87683-77-0."

Gene Ontology (GO) codes