N-carbamoyl-D-amino acid hydrolase

N-carbamoyl-D-amino acid hydrolase
N-carbamoyl-D-amino acid hydrolase
Identifiers
EC number 3.5.1.77
CAS number 71768-08-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-carbamoyl-D-amino acid hydrolase (EC 3.5.1.77) is an enzyme that catalyzes the chemical reaction

N-carbamoyl-D-amino acid + H2O \rightleftharpoons D-amino acid + NH3 + CO2

Thus, the two substrates of this enzyme are N-carbamoyl-D-amino acid and H2O, whereas its 3 products are D-amino acid, NH3, and CO2.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is '.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1ERZ, 1UF4, 1UF5, 1UF7, 1UF8, 2GGK, and 2GGL.

References

  • Ogawa J, Shimizu S, Yamada H (1993). "N-carbamoyl-D-amino acid amidohydrolase from Comamonas sp. E222c purification and characterization". Eur. J. Biochem. 212 (3): 685–91. doi:10.1111/j.1432-1033.1993.tb17706.x. PMID 8462543.