- Creatinine deaminase
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creatinine deaminase Identifiers EC number 3.5.4.21 CAS number 37289-15-9 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a creatinine deaminase (EC 3.5.4.21) is an enzyme that catalyzes the chemical reaction
- creatinine + H2O
N-methylhydantoin + NH3
Thus, the two substrates of this enzyme are creatinine and H2O, whereas its two products are N-methylhydantoin and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is creatinine iminohydrolase. Other names in common use include creatinine hydrolase, and creatinine desiminase. This enzyme participates in arginine and proline metabolism.
References
- Szulmajster J (1958). "Bacterial degradation of creatinine. II. Creatinine desimidase". Biochim. Biophys. Acta 30 (1): 154–163. doi:10.1016/0006-3002(58)90252-X. PMID 13584408.
This hydrolase article is a stub. You can help Wikipedia by expanding it. - creatinine + H2O
