Cyanoalanine nitrilase

Cyanoalanine nitrilase
cyanoalanine nitrilase
Identifiers
EC number 3.5.5.4
CAS number 85638-44-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cyanoalanine nitrilase (EC 3.5.5.4) is an enzyme that catalyzes the chemical reaction

3-cyano-L-alanine + 2 H2O \rightleftharpoons L-aspartate + NH3

Thus, the two substrates of this enzyme are 3-cyano-L-alanine and H2O, whereas its two products are L-aspartate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is 3-cyano-L-alanine aminohydrolase. This enzyme is also called beta-cyanoalanine nitrilase. This enzyme participates in cyanoamino acid metabolism.

References

  • Yanase H, Sakai T and Tonomuro K (1983). "Purification, crystallization and some properties of beta-cyano-L-alanine-degrading enzyme in Pseudomonas sp. 13". Agric. Biol. Chem. 47 (3): 473–482. doi:10.1271/bbb1961.47.473.