N-acetylgalactosamine-6-sulfatase

N-acetylgalactosamine-6-sulfatase
Identifiers
EC number	3.1.6.4
CAS number	9025-60-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) is an enzyme that catalyzes the chemical reaction of cleaving off the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of the macromolecule chondroitin sulfate and, similarly, of the D-galactose 6-sulfate units of the macromolecule keratan sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase. Other names in common use include chondroitin sulfatase, chondroitinase, galactose-6-sulfate sulfatase, acetylgalactosamine 6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, and N-acetylgalactosamine 6-sulfatase. This enzyme participates in glycosaminoglycan degradation and degradation of glycan structures.

References

• Epstein EH Jr, Leventhal ME (1981). "Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis". J. Clin. Invest. 67 (5): 1257–62. doi:10.1172/JCI110153. PMC 370691. PMID 6939689. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=370691. 
• Glossl J, Kresse H (1982). "Impaired degradation of keratan sulphate by Morquio A fibroblasts". Biochem. J. 203 (1): 335–8. PMC 1158229. PMID 6213226. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1158229. 
• Lim CT, Horwitz AL (1981). "Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase". Biochim. Biophys. Acta. 657 (2): 344–55. PMID 7213753. 
• Sorensen SH, Noren O, Sjostrom H, Danielsen EM (1982). "Amphiphilic pig intestinal microvillus maltase/glucoamylase Structure and specificity". Eur. J. Biochem. 126 (3): 559–68. doi:10.1111/j.1432-1033.1982.tb06817.x. PMID 6814909. 
• Yutaka T, Okada S, Kato T, Inui K, Yabuuhi H (1982). "Galactose 6-sulfate sulfatase activity in Morquio syndrome". Clin. Chim. Acta. 122 (2): 169–80. doi:10.1016/0009-8981(82)90276-5. PMID 6809361. 

This hydrolase article is a stub. You can help Wikipedia by expanding it.v · Categories: Hydrolase stubs EC 3.1.6 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Phosphoserine phosphatase Poly(3-hydroxybutyrate) depolymerase Look at other dictionaries: N-acetylgalactosamine-4-sulfatase — N ac·e·tyl·ga·lac·to·sa·mine 4 sul·fa·tase (as″ə təl ) (as″ə tēl″gal ak tōsґə mēn sulґfə tās) [EC 3.1.6.12] a lysosomal enzyme of the hydrolase class that catalyzes the cleavage of… …   Medical dictionary N-acetylgalactosamine-6-sulfatase — N ac·e·tyl·ga·lac·to·sa·mine 6 sul·fa·tase (as″ə təl ) (as″ə tēl gal″ak tōsґə mēn sulґfə tās) [EC 3.1.6.4] a lysosomal enzyme of the hydrolase class that catalyzes the cleavage of the …   Medical dictionary Sulfatase — Pfam box Symbol = Sulfatase Name = width =200 caption =Steryl sulfatase Pfam= PF00884 InterPro= IPR000917 SMART= PROSITE = PDOC00117 SCOP = 1auk TCDB = OPM family= 24 OPM protein= 1p49 PDB=PDB3|1fsu :43 486 PDB3|1hdhB:3 501 PDB3|1p49A:25… …   Wikipedia Galactosamine-6 sulfatase — Galactosamine (N acetyl) 6 sulfate sulfatase Identifiers Symbols GALNS; FLJ17434; FLJ42844; FLJ98217; GALNAC6S; GAS; MPS4A External IDs …   Wikipedia galactosamine-6-sulfatase — gal·ac·to·sa·mine 6 sul·fa·tase (gal″ak toґsə mēn sulґfə tās) N acetylgalactosamine 6 sulfatase …   Medical dictionary arylsulfatase B — N acetylgalactosamine 4 sulfatase …   Medical dictionary List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français EC 3.1 — Le groupe EC3.1 est un groupe d hydrolases rassemblant les estérases, c est à dire les enzymes catalysant la réaction générale : R O R + H2O ⇌ R OH + R OH où R représente un acide quelconque et R son substrat. En fonction du milieu, l ester… …   Wikipédia en Français Mucopolysaccharidosis — MPS I redirects here. For zhuyin or bopomofo, a phonetic system for romanizing Chinese, also known as Mandarin Phonetic Symbols I, see Bopomofo. Mucopolysaccharidosis Classification and external resources ICD 10 E76 ICD 9 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”