Dolichyl-phosphatase

dolichyl-phosphatase
Identifiers
EC number	3.1.3.51
CAS number	72994-50-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a dolichyl-phosphatase (EC 3.1.3.51) is an enzyme that catalyzes the chemical reaction

dolichyl phosphate + H₂O $\rightleftharpoons$ dolichol + phosphate

Thus, the two substrates of this enzyme are dolichyl phosphate and H₂O, whereas its two products are dolichol and phosphate.

This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name of this enzyme class is dolichyl-phosphate phosphohydrolase. Other names in common use include dolichol phosphate phosphatase, dolichol phosphatase, dolichol monophosphatase, dolichyl monophosphate phosphatase, dolichyl phosphate phosphatase, polyisoprenyl phosphate phosphatase, polyprenylphosphate phosphatase, and Dol-P phosphatase. This enzyme participates in n-glycan biosynthesis.

References

• Adrian GS, Keenan RW (1979). "A dolichyl phosphate-cleaving acid phosphatase from Tetrahymena pyriformis". Biochim. Biophys. Acta. 575 (3): 431–8. PMID 229909. 
• Rip JW, Rupar CA, Chaudhary N, Carroll KK (1981). "Localization of a dolichyl phosphate phosphatase in plasma membranes of rat liver". J. Biol. Chem. 256 (4): 1929–34. PMID 6257694. 
• Wedgwood JF, Strominger JL (1980). "Enzymatic activities in cultured human lymphocytes that dephosphorylate dolichyl pyrophosphate and dolichyl phosphate". J. Biol. Chem. 255 (3): 1120–3. PMID 6243292. 

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