Dolichylphosphate-glucose phosphodiesterase

Dolichylphosphate-glucose phosphodiesterase
dolichylphosphate-glucose phosphodiesterase
Identifiers
EC number 3.1.4.48
CAS number 89287-42-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dolichylphosphate-glucose phosphodiesterase (EC 3.1.4.48) is an enzyme that catalyzes the chemical reaction

dolichyl beta-D-glucosyl phosphate + H2O \rightleftharpoons dolichyl phosphate + D-glucose

Thus, the two substrates of this enzyme are dolichyl beta-D-glucosyl phosphate and H2O, whereas its two products are dolichyl phosphate and D-glucose.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase. Other names in common use include dolichol phosphoglucose phosphodiesterase, and Dol-P-Glc phosphodiesterase. This enzyme participates in n-glycan biosynthesis.

References

  • Crean EV (1984). "Synthesis and degradation of dolichyl phosphoryl glucose by the cellular slime mold, Dictyostelium discoideum". Biochim. Biophys. Acta 792: 149–157.