Dolichylphosphate-mannose phosphodiesterase

Dolichylphosphate-mannose phosphodiesterase
dolichylphosphate-mannose phosphodiesterase
Identifiers
EC number 3.1.4.49
CAS number 111839-07-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dolichylphosphate-mannose phosphodiesterase (EC 3.1.4.49) is an enzyme that catalyzes the chemical reaction

dolichyl beta-D-mannosyl phosphate + H2O \rightleftharpoons dolichyl phosphate + D-mannose

Thus, the two substrates of this enzyme are dolichyl beta-D-mannosyl phosphate and H2O, whereas its two products are dolichyl phosphate and D-mannose.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase. This enzyme is also called mannosylphosphodolichol phosphodiesterase.

References

  • Tomita Y, Motokawa Y (1987). "Characterization and partial purification of a novel mannosylphosphodolichol phosphodiesterase from chicken liver microsomes". Eur. J. Biochem. 170 (1–2): 363–8. doi:10.1111/j.1432-1033.1987.tb13708.x. PMID 2826159.