Dolichyldiphosphatase

Dolichyldiphosphatase
dolichyldiphosphatase
Identifiers
EC number 3.6.1.43
CAS number 73361-26-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dolichyldiphosphatase (EC 3.6.1.43) is an enzyme that catalyzes the chemical reaction

dolichyl diphosphate + H2O \rightleftharpoons dolichyl phosphate + phosphate

Thus, the two substrates of this enzyme are dolichyl diphosphate and H2O, whereas its two products are dolichyl phosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dolichyl-diphosphate phosphohydrolase. Other names in common use include dolichol diphosphatase, dolichyl pyrophosphatase, dolichyl pyrophosphate phosphatase, dolichyl diphosphate phosphohydrolase, and Dol-P-P phosphohydrolase. This enzyme participates in n-glycan biosynthesis.

References

  • Naumov AV, Shabalin YA, Vagabov VM and Kulaev IS (Moscow). "Two pathways of dephosphorylation of dolichyl diphosphate in yeasts". B Biochemistry: 551–556. 
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