Phosphoribosylaminoimidazolesuccinocarboxamide synthase

In enzymology, a phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC number|6.3.2.6) is an enzyme that catalyzes the chemical reaction

:ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate $ightleftharpoons$ ADP + phosphate + (S)-2- [5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido] succinate

The 3 substrates of this enzyme are ATP, 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, and L-aspartate, whereas its 4 products are ADP, phosphate, [(S)-2- [5-amino-1-(5-phospho-D-ribosyl)imidazole-4-] , and carboxamido] succinate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming). Other names in common use include phosphoribosylaminoimidazole-succinocarboxamide synthetase, PurC, SAICAR synthetase, 4-(N-succinocarboxamide)-5-aminoimidazole synthetase, 4- [(N-succinylamino)carbonyl] -5-aminoimidazole ribonucleotide, synthetase, SAICARs, phosphoribosylaminoimidazolesuccinocarboxamide synthetase, and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase. This enzyme participates in purine metabolism.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A48, PDB link|1KUT, PDB link|1OBD, PDB link|1OBG, PDB link|2CNQ, PDB link|2CNU, PDB link|2CNV, PDB link|2GQR, PDB link|2GQS, and PDB link|2H31.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-67-0."

Gene Ontology (GO) codes