Phosphoribosylformylglycinamidine cyclo-ligase

Phosphoribosylformylglycinamidine cyclo-ligase

In enzymology, a phosphoribosylformylglycinamidine cyclo-ligase (EC number| is an enzyme that catalyzes the chemical reaction

:ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine ightleftharpoons ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole

Thus, the two substrates of this enzyme are ATP and 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine, whereas its 3 products are ADP, phosphate, and 5-amino-1-(5-phospho-D-ribosyl)imidazole.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is 2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming). Other names in common use include phosphoribosylaminoimidazole synthetase, AIR synthetase, 5'-aminoimidazole ribonucleotide synthetase, 2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase, and (ADP-forming). This enzyme participates in purine metabolism.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1CLI, PDB link|2BTU, PDB link|2QK4, and PDB link|2V9Y.



External links

::"The CAS registry number for this enzyme class is CAS registry|9023-53-4."

Gene Ontology (GO) codes

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  • List of EC numbers (EC 6) — This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 6.1: Forming Carbon Oxygen… …   Wikipedia

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