Malonate CoA-transferase

Malonate CoA-transferase
malonate CoA-transferase
Identifiers
EC number 2.8.3.3
CAS number 9026-18-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a malonate CoA-transferase (EC 2.8.3.3) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + malonate \rightleftharpoons acetate + malonyl-CoA

Thus, the two substrates of this enzyme are acetyl-CoA and malonate, whereas its two products are acetate and malonyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is acetyl-CoA:malonate CoA-transferase. This enzyme is also called malonate coenzyme A-transferase. This enzyme participates in beta-alanine metabolism and propanoate metabolism.

References

  • HAYAISHI O (1955). "Enzymatic decarboxylation of malonic acid". J. Biol. Chem. 215 (1): 125–36. PMID 14392148. 
  • Takamura Y and Kitayama Y (1981). "Purification and some properties of malonate decarboxylase from Pseudomonas ovalis: an oligomeric enzyme with bifunctional properties". Biochem. Int. 3: 483–491. 
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