NAD(P)H oxidase

NAD(P)H oxidase
NAD(P)H oxidase
Identifiers
EC number 1.6.3.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a NAD(P)H oxidase (EC 1.6.3.1) is an enzyme that catalyzes the chemical reaction

NAD(P)H + H+ + O2 \rightleftharpoons NAD(P)+ + H2O2

The 4 substrates of this enzyme are NADH, NADPH, H+, and O2, whereas its 3 products are NAD+, NADP+, and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with oxygen as acceptor. The systematic name of this enzyme class is NAD(P)H:oxygen oxidoreductase. Other names in common use include THOX2, ThOX, dual oxidase, p138tox, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, and NADPH oxidase.

References

  • Vijlder JJ, Vulsma T, Ris-Stalpers C (2002). "Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism". N. Engl. J. Med. 347 (2): 95–102. doi:10.1056/NEJMoa012752. PMID 12110737. 
  • De Deken X, Wang D, Dumont JE, Miot F (2002). "Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system". Exp. Cell. Res. 273 (2): 187–96. doi:10.1006/excr.2001.5444. PMID 11822874. 
  • Dumont JE, Miot F (2000). "Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family". J. Biol. Chem. 275 (30): 23227–33. doi:10.1074/jbc.M000916200. PMID 10806195. 
  • Dupuy C, Ohayon R, Valent A, Noel-Hudson MS, Deme D, Virion A (1999). "Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas". J. Biol. Chem. 274 (52): 37265–9. doi:10.1074/jbc.274.52.37265. PMID 10601291. 
  • Carvalho D, Dupuy C, Virion A (1999). "Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue". Biochimie. 81 (4): 373–80. doi:10.1016/S0300-9084(99)80084-4. PMID 10401672. 
  • Dupuy C, Virion A, Ohayon R, Kaniewski J, Deme D, Pommier J (1991). "Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane". J. Biol. Chem. 266 (6): 3739–43. PMID 1995628. 
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