Aspartate dehydrogenase

Aspartate dehydrogenase

In enzymology, an aspartate dehydrogenase (EC number|1.4.1.21) is an enzyme that catalyzes the chemical reaction

:L-aspartate + H2O + NAD(P)+ ightleftharpoons oxaloacetate + NH3 + NAD(P)H + H+

The 4 substrates of this enzyme are L-aspartate, H2O, NAD+, and NADP+, whereas its 5 products are oxaloacetate, NH3, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-aspartate:NAD(P)+ oxidoreductase (deaminating). Other names in common use include NAD-dependent aspartate dehydrogenase, NADH2-dependent aspartate dehydrogenase, and NADP+-dependent aspartate dehydrogenase. This enzyme participates in nicotinate and nicotinamide metabolism.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2DC1.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37278-97-0."


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