NADPH peroxidase

NADPH peroxidase
NADPH peroxidase
Identifiers
EC number 1.11.1.2
CAS number 9029-51-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a NADPH peroxidase (EC 1.11.1.2) is an enzyme that catalyzes the chemical reaction

NADPH + H+ + H2O2 \rightleftharpoons NADP+ + 2 H2O

The 3 substrates of this enzyme are NADPH, H+, and H2O2, whereas its two products are NADP+ and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is NADPH:hydrogen-peroxide oxidoreductase. Other names in common use include TPNH peroxidase, NADP peroxidase, nicotinamide adenine dinucleotide phosphate peroxidase, TPN peroxidase, triphosphopyridine nucleotide peroxidase, and NADPH2 peroxidase.

References

  • CONN EE, KRAEMER LM, LIU PN, VENNESLAND B (1952). "The aerobic oxidation of reduced triphosphopyridine nucleotide by a wheat germ enzyme system". J. Biol. Chem. 194 (1): 143–51. PMID 14927602.