NADH peroxidase

NADH peroxidase
NADH peroxidase
Identifiers
EC number 1.11.1.1
CAS number 9032-24-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a NADH peroxidase (EC 1.11.1.1) is an enzyme that catalyzes the chemical reaction

NADH + H+ + H2O2 \rightleftharpoons NAD+ + 2 H2O

The 3 substrates of this enzyme are NADH, H+, and H2O2, whereas its two products are NAD+ and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is NADH:hydrogen-peroxide oxidoreductase. Other names in common use include DPNH peroxidase, NAD peroxidase, diphosphopyridine nucleotide peroxidase, NADH-peroxidase, nicotinamide adenine dinucleotide peroxidase, and NADH2 peroxidase. It employs one cofactor, FAD.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1F8W, 1JOA, 1NHP, 1NHQ, 1NHR, 1NHS, 1NPX, and 2NPX.

References

  • Domagk GF and Horecker BL (1965). "Fructose and erythrose metabolism in Alcaligenes faecalis". Arch. Biochem. Biophys. 109 (2): 342–349. doi:10.1016/0003-9861(65)90371-1. 
  • Mizushima S and Kitahara K (1962). "Purification and properties of DPNH peroxidase in Lactobacillus casei". J. Gen. Appl. Microbiol. 8: 56–62. doi:10.2323/jgam.8.56. 
  • Walker GA, Kilgour GL (1965). "Pyridine nucleotide oxidizing enzymes of Lactobacillus casei. II Oxidase and peroxidase". Arch. Biochem. Biophys. 111 (3): 534–9. doi:10.1016/0003-9861(65)90232-8. PMID 4285876. 
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