Chloride peroxidase

chloride peroxidase
Identifiers
EC number	1.11.1.10
CAS number	9055-20-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a chloride peroxidase (EC 1.11.1.10) is an enzyme that catalyzes the chemical reaction

2 RH + 2 Cl- + H₂O₂ $\rightleftharpoons$ 2 RCl + 2 H₂O

The 3 substrates of this enzyme are RH, Cl⁻, and H₂O₂, whereas its two products are RCl and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is chloride:hydrogen-peroxide oxidoreductase. This enzyme is also called chloroperoxidase. It employs one cofactor which may be either heme or vanadia.

Chloroperoxidases are heme or vanadium-containing enzymes that exhibits peroxidase, catalase and cytochrome P450-like activities in addition to catalyzing halogenation reactions^[1]. Despite functional similarities with other heme enzymes, CPO folds into a novel tertiary structure dominated by eight helical segments. The catalytic base, required to cleave the peroxide O-O bond, is glutamic acid rather than histidine as in other peroxidases.

Structural studies

As of late 2007, 30 structures have been solved for this class of enzymes, with PDB accession codes 1A7U, 1A88, 1A8Q, 1A8S, 1A8U, 1BRT, 1CPO, 1IDQ, 1IDU, 1QHB, 1QI9, 1VNC, 1VNE, 1VNF, 1VNG, 1VNH, 1VNI, 1VNS, 2CIV, 2CIW, 2CIX, 2CIY, 2CIZ, 2CJ0, 2CJ1, 2CJ2, 2CPO, 2J18, 2J19, and 2J5M.

References

1. ^ Poulos TL, Sundaramoorthy M, Terner J (1995). "The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid". Structure 3 (12): 1367–1377. doi:10.1016/S0969-2126(01)00274-X. PMID 8747463. 

• Hager LP, Hollenberg PF, Rand-Meir T, Chiang R, Doubek D (1975). "Chemistry of peroxidase intermediates". Ann. N. Y. Acad. Sci. 244: 80–93. doi:10.1111/j.1749-6632.1975.tb41524.x. PMID 1056179. 
• Morris DR, Hager LP (1966). "Chloroperoxidase. I. Isolation and properties of the crystalline glycoprotein". J. Biol. Chem. 241 (8): 1763–8. PMID 5949836. 
• Theiler R, Cook JC, Hager LP and Siuda JF (1978). "Halohydrocarbon synthesis by homoperoxidase". Science 202 (4372): 1094–1096. doi:10.1126/science.202.4372.1094. PMID 17777960. 

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