Aryl-aldehyde dehydrogenase (NADP+)

Aryl-aldehyde dehydrogenase (NADP+)
aryl-aldehyde dehydrogenase (NADP+)
Identifiers
EC number 1.2.1.30
CAS number 9074-94-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an aryl-aldehyde dehydrogenase (NADP+) (EC 1.2.1.30) is an enzyme that catalyzes the chemical reaction

an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O \rightleftharpoons an aromatic acid + NADPH + H+ + ATP

The 5 substrates of this enzyme are aromatic aldehyde, NADP+, AMP, diphosphate, and H2O, whereas its 4 products are aromatic acid, NADPH, H+, and ATP.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aryl-aldehyde:NADP+ oxidoreductase (ATP-forming). Other names in common use include aromatic acid reductase, and aryl-aldehyde dehydrogenase (NADP+).

References

  • Gross GG (1972). "Formation and reduction of intermediate acyladenylate by aryl-aldehyde. NADP oxidoreductase from Neurospora crassa". Eur. J. Biochem. 31 (3): 585–92. doi:10.1111/j.1432-1033.1972.tb02569.x. PMID 4405494. 
  • Gross GG, Zenk MH (1969). "[Reduction of aromatic acids to aldehydes and alcohols in the cell-free system. 1. Purification and properties of aryl-aldehyde: NADP-oxidoreductase from Neurospora crassa]". Eur. J. Biochem. 8 (3): 413–9. doi:10.1111/j.1432-1033.1969.tb00543.x. PMID 4389863. 
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