FOXO3A

Forkhead box O3A, also known as FOXO3A, is a human gene.cite journal | author = Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC | title = Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily | journal = Genomics | volume = 47 | issue = 2 | pages = 187–99 | year = 1998 | month = January | pmid = 9479491 | doi = 10.1006/geno.1997.5122 | url = | issn = ]

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death, such as "Bim" and "Puma". Deregulation of FOXO3a is involved in tumourigenesis,cite journal | author = Myatt SS, Lam EW | title = The emerging roles of forkhead box (Fox) proteins in cancer | journal = Nat. Rev. Cancer | volume = 7 | issue = 11 | pages = 847–59 | year = 2007 | month = November | pmid = 17943136 | doi = 10.1038/nrc2223 | url = | issn = ] for example translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.cite web | title = Entrez Gene: FOXO3A forkhead box O3A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2309| accessdate = ]

ee also

* FOX proteins

References

Further reading

*cite journal | author=Stahl M, et al. |title=The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. |journal=J. Immunol |volume=168 |issue= |pages= 5024–5031 |year= 2002 |pmid=11994454 |doi= PBB_Further_reading
citations =
*cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013
*cite journal | author=Hillion J, Le Coniat M, Jonveaux P, "et al." |title=AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. |journal=Blood |volume=90 |issue= 9 |pages= 3714–9 |year= 1997 |pmid= 9345057 |doi=
*cite journal | author=Anderson MJ, Viars CS, Czekay S, "et al." |title=Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. |journal=Genomics |volume=47 |issue= 2 |pages= 187–99 |year= 1998 |pmid= 9479491 |doi= 10.1006/geno.1997.5122
*cite journal | author=DaSilva L, Kirken RA, Taub DD, "et al." |title=Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family. |journal=Gene |volume=221 |issue= 1 |pages= 135–42 |year= 1998 |pmid= 9852958 |doi=
*cite journal | author=Brunet A, Bonni A, Zigmond MJ, "et al." |title=Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. |journal=Cell |volume=96 |issue= 6 |pages= 857–68 |year= 1999 |pmid= 10102273 |doi=
*cite journal | author=Medema RH, Kops GJ, Bos JL, Burgering BM |title=AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. |journal=Nature |volume=404 |issue= 6779 |pages= 782–7 |year= 2000 |pmid= 10783894 |doi= 10.1038/35008115
*cite journal | author=Brunet A, Park J, Tran H, "et al." |title=Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). |journal=Mol. Cell. Biol. |volume=21 |issue= 3 |pages= 952–65 |year= 2001 |pmid= 11154281 |doi= 10.1128/MCB.21.3.952-965.2001
*cite journal | author=Schuur ER, Loktev AV, Sharma M, "et al." |title=Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33554–60 |year= 2001 |pmid= 11435445 |doi= 10.1074/jbc.M105555200
*cite journal | author=Kops GJ, Medema RH, Glassford J, "et al." |title=Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. |journal=Mol. Cell. Biol. |volume=22 |issue= 7 |pages= 2025–36 |year= 2002 |pmid= 11884591 |doi=
*cite journal | author=Mahmud DL, G-Amlak M, Deb DK, "et al." |title=Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. |journal=Oncogene |volume=21 |issue= 10 |pages= 1556–62 |year= 2002 |pmid= 11896584 |doi= 10.1038/sj.onc.1205230
*cite journal | author=Nadal A, Marrero PF, Haro D |title=Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1. |journal=Biochem. J. |volume=366 |issue= Pt 1 |pages= 289–97 |year= 2002 |pmid= 12027802 |doi= 10.1042/BJ20020598
*cite journal | author=Wistow G, Bernstein SL, Wyatt MK, "et al." |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue= |pages= 205–20 |year= 2002 |pmid= 12107410 |doi=
*cite journal | author=Modur V, Nagarajan R, Evers BM, Milbrandt J |title=FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47928–37 |year= 2003 |pmid= 12351634 |doi= 10.1074/jbc.M207509200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Charvet C, Alberti I, Luciano F, "et al." |title=Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases. |journal=Oncogene |volume=22 |issue= 29 |pages= 4557–68 |year= 2003 |pmid= 12881712 |doi= 10.1038/sj.onc.1206778
*cite journal | author=Crossley LJ |title=Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1. |journal=J. Leukoc. Biol. |volume=74 |issue= 4 |pages= 583–92 |year= 2003 |pmid= 12960271 |doi= 10.1189/jlb.0103020
*cite journal | author=Sunters A, Fernández de Mattos S, Stahl M, "et al." |title=FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49795–805 |year= 2004 |pmid= 14527951 |doi= 10.1074/jbc.M309523200
*cite journal | author=Skurk C, Maatz H, Kim HS, "et al." |title=The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1513–25 |year= 2004 |pmid= 14551207 |doi= 10.1074/jbc.M304736200
*cite journal | author=Dansen TB, Kops GJ, Denis S, "et al." |title=Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a. |journal=J. Lipid Res. |volume=45 |issue= 1 |pages= 81–8 |year= 2004 |pmid= 14563822 |doi= 10.1194/jlr.M300111-JLR200
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055

External links

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