BCL2L11

BCL2-like 11 (apoptosis facilitator), also known as BCL2L11, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [cite web | title = Entrez Gene: BCL2L11 BCL2-like 11 (apoptosis facilitator)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10018| accessdate = ]

ee also

* Bcl-2

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wang K, Yin XM, Chao DT, "et al." |title=BID: a novel BH3 domain-only death agonist. |journal=Genes Dev. |volume=10 |issue= 22 |pages= 2859–69 |year= 1996 |pmid= 8918887 |doi=
*cite journal | author=Zha J, Harada H, Yang E, "et al." |title=Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) |journal=Cell |volume=87 |issue= 4 |pages= 619–28 |year= 1997 |pmid= 8929531 |doi=
*cite journal | author=O'Connor L, Strasser A, O'Reilly LA, "et al." |title=Bim: a novel member of the Bcl-2 family that promotes apoptosis. |journal=EMBO J. |volume=17 |issue= 2 |pages= 384–95 |year= 1998 |pmid= 9430630 |doi= 10.1093/emboj/17.2.384
*cite journal | author=Huang DC, Adams JM, Cory S |title=The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. |journal=EMBO J. |volume=17 |issue= 4 |pages= 1029–39 |year= 1998 |pmid= 9463381 |doi= 10.1093/emboj/17.4.1029
*cite journal | author=Hsu SY, Lin P, Hsueh AJ |title=BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. |journal=Mol. Endocrinol. |volume=12 |issue= 9 |pages= 1432–40 |year= 1998 |pmid= 9731710 |doi=
*cite journal | author=Puthalakath H, Huang DC, O'Reilly LA, "et al." |title=The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 287–96 |year= 1999 |pmid= 10198631 |doi=
*cite journal | author=Ohi N, Tokunaga A, Tsunoda H, "et al." |title=A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 314–25 |year= 1999 |pmid= 10381623 |doi= 10.1038/sj.cdd.4400493
*cite journal | author=Bouillet P, Metcalf D, Huang DC, "et al." |title=Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. |journal=Science |volume=286 |issue= 5445 |pages= 1735–8 |year= 1999 |pmid= 10576740 |doi=
*cite journal | author=Bae J, Leo CP, Hsu SY, Hsueh AJ |title=MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25255–61 |year= 2000 |pmid= 10837489 |doi= 10.1074/jbc.M909826199
*cite journal | author=Dijkers PF, Medema RH, Lammers JW, "et al." |title=Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. |journal=Curr. Biol. |volume=10 |issue= 19 |pages= 1201–4 |year= 2000 |pmid= 11050388 |doi=
*cite journal | author=Bouillet P, Zhang LC, Huang DC, "et al." |title=Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim. |journal=Mamm. Genome |volume=12 |issue= 2 |pages= 163–8 |year= 2001 |pmid= 11210187 |doi=
*cite journal | author=Putcha GV, Moulder KL, Golden JP, "et al." |title=Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis. |journal=Neuron |volume=29 |issue= 3 |pages= 615–28 |year= 2001 |pmid= 11301022 |doi=
*cite journal | author=Murray S, Halford S, Ebenezer ND, "et al." |title=Assignment of BCL2L11 to human chromosome band 2p13 with somatic cell and radiation hybrids. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3-4 |pages= 353 |year= 2001 |pmid= 11435715 |doi=
*cite journal | author=Cheng EH, Wei MC, Weiler S, "et al." |title=BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 705–11 |year= 2001 |pmid= 11583631 |doi=
*cite journal | author=U M, Miyashita T, Shikama Y, "et al." |title=Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family. |journal=FEBS Lett. |volume=509 |issue= 1 |pages= 135–41 |year= 2002 |pmid= 11734221 |doi=
*cite journal | author=Bouillet P, Purton JF, Godfrey DI, "et al." |title=BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. |journal=Nature |volume=415 |issue= 6874 |pages= 922–6 |year= 2002 |pmid= 11859372 |doi= 10.1038/415922a
*cite journal | author=Marani M, Tenev T, Hancock D, "et al." |title=Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3577–89 |year= 2002 |pmid= 11997495 |doi=
*cite journal | author=Liu JW, Chandra D, Tang SH, "et al." |title=Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. |journal=Cancer Res. |volume=62 |issue= 10 |pages= 2976–81 |year= 2002 |pmid= 12019181 |doi=
*cite journal | author=Terradillos O, Montessuit S, Huang DC, Martinou JC |title=Direct addition of BimL to mitochondria does not lead to cytochrome c release. |journal=FEBS Lett. |volume=522 |issue= 1-3 |pages= 29–34 |year= 2002 |pmid= 12095614 |doi=
*cite journal | author=Sugiyama T, Shimizu S, Matsuoka Y, "et al." |title=Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim. |journal=Oncogene |volume=21 |issue= 32 |pages= 4944–56 |year= 2002 |pmid= 12118373 |doi= 10.1038/sj.onc.1205621

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