P53 upregulated modulator of apoptosis
- P53 upregulated modulator of apoptosis
protein
Name = BCL2 binding component 3
caption =
width =
HGNCid = 17868
Symbol = BBC3
AltSymbols = JFY1, PUMA
EntrezGene = 27113
OMIM = 605854
RefSeq = NM_014417
UniProt =
PDB =
ECnumber =
Chromosome = 19
Arm = q
Band = 13.3
LocusSupplementaryData = -13.4The p53 upregulated modulator of apoptosis, or PUMA, is a pro-apoptotic member of the Bcl-2 protein family.[cite journal | author = Nakano K, Vousden KH | title = PUMA, a novel proapoptotic gene, is induced by p53 | journal = Mol. Cell | volume = 7 | issue = 3 | pages = 683–94 | year = 2001 | month = March | pmid = 11463392 | doi = 10.1016/S1097-2765(01)00214-3 | url = | issn = ] ][cite journal | author = Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T | title = Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 20 | pages = 11318–23 | year = 2001 | month = September | pmid = 11572983 | pmc = 58727 | doi = 10.1073/pnas.201208798 | url = | issn = ] ]Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of PUMA is regulated by the tumor suppressor p53, and PUMA has been shown to be involved in p53-mediated apoptosis.
ee also
* Apoptosis
* Apoptosome
* Bcl-2
* Bcl-2-associated_X_protein (BAX)
* BH3 interacting domain death agonist (BID)
* Caspases
* Cytochrome c
* Noxa
* Mitochondrion
References
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2010.
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