Malate oxidase

Malate oxidase
malate oxidase
Identifiers
EC number 1.1.3.3
CAS number 9028-73-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a malate oxidase (EC 1.1.3.3) is an enzyme that catalyzes the chemical reaction

(S)-malate + O2 \rightleftharpoons oxaloacetate + H2O2

Thus, the two substrates of this enzyme are (S)-malate and O2, whereas its two products are oxaloacetate and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is (S)-malate:oxygen oxidoreductase. Other names in common use include FAD-dependent malate oxidase, malic oxidase, and malic dehydrogenase II. This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.

References

  • COHN DV (1958). "The enzymatic formation of oxalacetic acid by nonpyridine nucleotide malic dehydrogenase of Micrococcus lysodeikticus". J. Biol. Chem. 233 (2): 299–304. PMID 13563491. 
  • Narindrasorasak S, Goldie AH, Sanwal BD (1979). "Characteristics and regulation of a phospholipid-activated malate oxidase from Escherichia coli". J. Biol. Chem. 254 (5): 1540–5. PMID 368072. 
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