PDE4D

Phosphodiesterase 4D, cAMP-specific
PDB rendering based on 1mkd.
Available structures PDB 1E9K, 1MKD, 1OYN, 1PTW, 1Q9M, 1TB7, 1TBB, 1XOM, 1XON, 1XOQ, 1XOR, 1Y2B, 1Y2C, 1Y2D, 1Y2E, 1Y2K, 1ZKN, 2FM0, 2FM5, 2PW3, 2QYN, 3G4G, 3G4I, 3G4K, 3G4L, 3G58, 3IAD, 3IAK, 3K4S
Identifiers
Symbols	PDE4D; DKFZp686M11213; DPDE3; FLJ97311; HSPDE4D; PDE43; PDE4DN2; STRK1
External IDs	OMIM: 600129 MGI: 99555 HomoloGene: 710 GeneCards: PDE4D Gene
EC number	3.1.4.17
Gene Ontology Molecular function • 3',5'-cyclic-nucleotide phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity • phosphoric diester hydrolase activity • hydrolase activity • metal ion binding Cellular component • soluble fraction • insoluble fraction • cytoplasm • microtubule organizing center • cytosol • cytosol • cytoskeleton • membrane Biological process • signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5144	238871
Ensembl	ENSG00000113448	ENSMUSG00000021699
UniProt	Q08499	Q01063
RefSeq (mRNA)	NM_001104631.1	NM_011056
RefSeq (protein)	NP_001098101.1	NP_035186
Location (UCSC)	Chr 5: 58.26 – 59.82 Mb	Chr 13: 110.15 – 111.07 Mb
PubMed search	[1]	[2]

cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.

The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM]^[1]

Interactions

PDE4D has been shown to interact with myomegalin^[2] and GNB2L1.^[3][4]

References

1. ^ "Entrez Gene: PDE4D phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5144. 
2. ^ Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, Onuffer J, Jin SL, Conti M (April 2001). "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". J. Biol. Chem. 276 (14): 11189–98. doi:10.1074/jbc.M006546200. PMID 11134006. 
3. ^ Yarwood SJ, Steele MR, Scotland G, Houslay MD, Bolger GB (May 1999). "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform". J. Biol. Chem. 274 (21): 14909–17. doi:10.1074/jbc.274.21.14909. PMID 10329691. 
4. ^ Steele MR, McCahill A, Thompson DS, MacKenzie C, Isaacs NW, Houslay MD, Bolger GB (July 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cell. Signal. 13 (7): 507–13. doi:10.1016/S0898-6568(01)00167-X. PMID 11516626. 

Further reading

• Wang Q (2005). "Molecular genetics of coronary artery disease". Curr. Opin. Cardiol. 20 (3): 182–8. doi:10.1097/01.hco.0000160373.77190.f1. PMC 1579824. PMID 15861005. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1579824. 
• Swinnen JV, Joseph DR, Conti M (1989). "The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8197–201. doi:10.1073/pnas.86.21.8197. PMC 298247. PMID 2554303. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=298247. 
• Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat. Cell Mol. Genet. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369. 
• Baecker PA, Obernolte R, Bach C, et al. (1994). "Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)". Gene 138 (1–2): 253–6. doi:10.1016/0378-1119(94)90818-4. PMID 8125310. 
• Bolger G, Michaeli T, Martins T, et al. (1993). "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs". Mol. Cell. Biol. 13 (10): 6558–71. PMC 364715. PMID 8413254. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=364715. 
• Sette C, Conti M (1996). "Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation". J. Biol. Chem. 271 (28): 16526–34. doi:10.1074/jbc.271.28.16526. PMID 8663227. 
• Némoz G, Zhang R, Sette C, Conti M (1996). "Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells". FEBS Lett. 384 (1): 97–102. doi:10.1016/0014-5793(96)00300-6. PMID 8797812. 
• Bolger GB, Erdogan S, Jones RE, et al. (1998). "Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene". Biochem. J. 328 ( Pt 2) (Pt 2): 539–48. PMC 1218953. PMID 9371713. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218953. 
• Hoffmann R, Baillie GS, MacKenzie SJ, et al. (1999). "The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579". EMBO J. 18 (4): 893–903. doi:10.1093/emboj/18.4.893. PMC 1171182. PMID 10022832. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171182. 
• Yarwood SJ, Steele MR, Scotland G, et al. (1999). "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform". J. Biol. Chem. 274 (21): 14909–17. doi:10.1074/jbc.274.21.14909. PMID 10329691. 
• Beard MB, O'Connell JC, Bolger GB, Houslay MD (1999). "The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains". FEBS Lett. 460 (1): 173–7. doi:10.1016/S0014-5793(99)01335-6. PMID 10571082. 
• MacKenzie SJ, Baillie GS, McPhee I, et al. (2000). "ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions". J. Biol. Chem. 275 (22): 16609–17. doi:10.1074/jbc.275.22.16609. PMID 10828059. 
• Miró X, Casacuberta JM, Gutiérrez-López MD, et al. (2000). "Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1)". Biochem. Biophys. Res. Commun. 274 (2): 415–21. doi:10.1006/bbrc.2000.3146. PMID 10913353. 
• Verde I, Pahlke G, Salanova M, et al. (2001). "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". J. Biol. Chem. 276 (14): 11189–98. doi:10.1074/jbc.M006546200. PMID 11134006. 
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. 
• Dodge KL, Khouangsathiene S, Kapiloff MS, et al. (2001). "mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module". EMBO J. 20 (8): 1921–30. doi:10.1093/emboj/20.8.1921. PMC 125429. PMID 11296225. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125429. 
• Steele MR, McCahill A, Thompson DS, et al. (2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cell. Signal. 13 (7): 507–13. doi:10.1016/S0898-6568(01)00167-X. PMID 11516626. 
• Gretarsdottir S, Sveinbjörnsdottir S, Jonsson HH, et al. (2002). "Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12". Am. J. Hum. Genet. 70 (3): 593–603. doi:10.1086/339252. PMC 384939. PMID 11833004. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=384939. 
• Moon E, Lee R, Near R, et al. (2002). "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia". Clin. Cancer Res. 8 (2): 589–95. PMID 11839681. 
• Le Jeune IR, Shepherd M, Van Heeke G, et al. (2002). "Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter". J. Biol. Chem. 277 (39): 35980–9. doi:10.1074/jbc.M204832200. PMID 12121997.