- Myomegalin
-
Phosphodiesterase 4D interacting protein Identifiers Symbols PDE4DIP; CMYA2; DKFZp781J054; MGC75440; MMGL External IDs OMIM: 608117 MGI: 1891434 HomoloGene: 66961 GeneCards: PDE4DIP Gene Gene Ontology Molecular function • protein binding
• enzyme bindingCellular component • nucleus
• cytoplasm
• Golgi apparatus
• centrosome
• centrosome
• cytoskeleton
• myofibrilBiological process • cellular protein complex assembly Sources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 9659 83679 Ensembl ENSG00000178104 ENSMUSG00000038170 UniProt Q5VU43 Q80YT7 RefSeq (mRNA) NM_001002810.3 NM_001039376 RefSeq (protein) NP_001002810.1 NP_001034465 Location (UCSC) Chr 1:
144.83 – 145.08 MbChr 3:
97.49 – 97.69 MbPubMed search [1] [2] Myomegalin also known as phosphodiesterase 4D-interacting protein or cardiomyopathy-associated protein 2 is a protein that in humans is encoded by the PDE4DIP gene.[1][2][3]
Contents
Interactions
PDE4DIP has been shown to interact with PDE4D.[2]
Related gene problems
- 1q21.1 deletion syndrome
- 1q21.1 duplication syndrome
References
- ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
- ^ a b Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, Onuffer J, Jin SL, Conti M (Apr 2001). "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". J Biol Chem 276 (14): 11189–98. doi:10.1074/jbc.M006546200. PMID 11134006.
- ^ "Entrez Gene: PDE4DIP phosphodiesterase 4D interacting protein (myomegalin)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9659.
Further reading
- Soejima H, Kawamoto S, Akai J, et al. (2001). "Isolation of novel heart-specific genes using the BodyMap database.". Genomics 74 (1): 115–20. doi:10.1006/geno.2001.6527. PMID 11374908.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Okazaki N, Kikuno R, Ohara R, et al. (2003). "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.". DNA Res. 10 (1): 35–48. doi:10.1093/dnares/10.1.35. PMID 12693553.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Shimada H, Kuboshima M, Shiratori T, et al. (2007). "Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma.". Int. J. Oncol. 30 (1): 97–103. PMID 17143517.
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