- Coproporphyrinogen dehydrogenase
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coproporphyrinogen dehydrogenase Identifiers EC number 1.3.99.22 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a coproporphyrinogen dehydrogenase (EC 1.3.99.22) is an enzyme that catalyzes the chemical reaction
- coproporphyrinogen III + 2 S-adenosyl-L-methionine
protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine
Thus, the two substrates of this enzyme are coproporphyrinogen III and S-adenosyl-L-methionine, whereas its 4 products are protoporphyrinogen IX, CO2, L-methionine, and 5'-deoxyadenosine.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating). Other names in common use include oxygen-independent coproporphyrinogen-III oxidase, HemN, radical SAM enzyme, and coproporphyrinogen III oxidase. This enzyme participates in porphyrin and chlorophyll metabolism.
References
- Layer G, Verfurth K, Mahlitz E, Jahn D (2002). "Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli". J. Biol. Chem. 277 (37): 34136–42. doi:10.1074/jbc.M205247200. PMID 12114526.
- Layer G, Moser J, Heinz DW, Jahn D, Schubert WD (2003). "Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes". EMBO J. 22 (23): 6214–24. doi:10.1093/emboj/cdg598. PMC 291839. PMID 14633981. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=291839.
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