Glycerate dehydrogenase

Glycerate dehydrogenase

In enzymology, a glycerate dehydrogenase (EC number|1.1.1.29) is an enzyme that catalyzes the chemical reaction

:(R)-glycerate + NAD+ ightleftharpoons hydroxypyruvate + NADH + H+

Thus, the two substrates of this enzyme are (R)-glycerate and NAD+, whereas its 3 products are hydroxypyruvate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-glycerate:NAD+ oxidoreductase. Other names in common use include D-glycerate dehydrogenase, and hydroxypyruvate reductase. This enzyme participates in glycine, serine and threonine metabolism and glyoxylate and dicarboxylate metabolism.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1GDH.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-37-9."

Gene Ontology (GO) codes


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