Glucuronolactone reductase

In enzymology, a glucuronolactone reductase (EC number|1.1.1.20) is an enzyme that catalyzes the chemical reaction

:L-gulono-1,4-lactone + NADP⁺ $ightleftharpoons$ D-glucurono-3,6-lactone + NADPH + H⁺

Thus, the two substrates of this enzyme are L-gulono-1,4-lactone and NADP⁺, whereas its 3 products are D-glucurono-3,6-lactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-gulono-1,4-lactone:NADP+ 1-oxidoreductase. Other names in common use include GRase, and gulonolactone dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-30-2."

Gene Ontology (GO) codes