D-xylose 1-dehydrogenase (NADP+)

D-xylose 1-dehydrogenase (NADP+)
D-xylose 1-dehydrogenase (NADP+)
Identifiers
EC number 1.1.1.179
CAS number 83534-37-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a D-xylose 1-dehydrogenase (NADP+) (EC 1.1.1.179) is an enzyme that catalyzes the chemical reaction

D-xylose + NADP+ \rightleftharpoons D-xylono-1,5-lactone + NADPH + H+

Thus, the two substrates of this enzyme are D-xylose and NADP+, whereas its 3 products are D-xylono-1,5-lactone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-xylose:NADP+ 1-oxidoreductase. Other names in common use include D-xylose (nicotinamide adenine dinucleotide phosphate), dehydrogenase, D-xylose-NADP+ dehydrogenase, D-xylose:NADP+ oxidoreductase, and D-xylose 1-dehydrogenase (NADP+).

References

  • Wissler JH (1977). "D-Xylose:NADP oxidoreductase of arterial vessels and eye lens: a new enzyme and a final link in ATP-independent cycling of reducing equivalents in aldose-polyol-ketose interconversion". Hoppe-Seyler's Z. Physiol. Chem. 358: 1300–1301. 
  • Wissler JH (1978). "Direct spectrophotometric and specific quantitative determination of free and bound D-xylose by analytical application of a new enzyme, D-xylose:NADP-oxidoreductase". Fresenius' Z. Anal. Chem. 290 (2): 179–180. doi:10.1007/BF00482334.