Codeinone reductase (NADPH)

Codeinone reductase (NADPH)
codeinone reductase (NADPH)
Identifiers
EC number 1.1.1.247
CAS number 153302-41-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a codeinone reductase (NADPH) (EC 1.1.1.247) is an enzyme that catalyzes the chemical reaction

codeine + NADP+ \rightleftharpoons codeinone + NADPH + H+

Thus, the two substrates of this enzyme are codeine and NADP+, whereas its 3 products are codeinone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is codeine:NADP+ oxidoreductase. This enzyme participates in alkaloid biosynthesis i.

References

  • Lenz R and Zenk MH (1995). "Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum". Tetrahedron Lett. 36 (14): 2449–2452. doi:10.1016/0040-4039(95)00278-K. 
  • Lenz R, Zenk MH (1995). "Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants". Eur. J. Biochem. 233 (1): 132–9. doi:10.1111/j.1432-1033.1995.132_1.x. PMID 7588736. 
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