Mini Chromosome Maintenance
- Mini Chromosome Maintenance
Pfam_box
Symbol = MCM
Name = MCM2/3/5 family
width =
caption =
Pfam = PF00493
InterPro = IPR001208
SMART =
PROSITE = PDOC00662
SCOP =
TCDB =
OPM family =
OPM protein =
PDB =
Mini Chromosome Maintenance complex, or Minichromosome Maintenance protein complex or mini-chromosome maintenance (MCM) 2-7 helicase complex has a role in both the initiation and the elongation phases of eukaryotic DNA replication, specifically the formation and elongation of the replication fork. MCM is a component of the pre-replication complex, which is a component of the licensing factor. MCM consists of six related polypeptides that form a ring structure.[cite journal | author = Cortez D, Glick G, Elledge SJ | title = Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 27 | pages = 10078–83 | year = 2004 | month = July | pmid = 15210935 | pmc = 454167 | doi = 10.1073/pnas.0403410101 | url = | issn = ] ][cite journal | author = Carpentieri F, De Felice M, De Falco M, Rossi M, Pisani FM | title = Physical and functional interaction between the mini-chromosome maintenance-like DNA helicase and the single-stranded DNA binding protein from the crenarchaeon Sulfolobus solfataricus | journal = J. Biol. Chem. | volume = 277 | issue = 14 | pages = 12118–27 | year = 2002 | month = April | pmid = 11821426 | doi = 10.1074/jbc.M200091200 | url = | issn = ] ]ee also
* Human genes encoding MCM proteins include:
** MCM2
** MCM3
** MCM4
** MCM5
** MCM6
** MCM7
References
External links
* cite web | url = http://focus.hms.harvard.edu/2001/Jan12_2001/pathology1.html | title = Molecular Bureaucrat Tied to Replication Approval Process | author = Humphries C | authorlink = | coauthors = | date = 2001-01-12 | format = | work = Focus | publisher = Harvard Medical, Dental, and Public Health Schools | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-10-03
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Minichromosome maintenance — MCM2/3/5 family Structure of MCM from archaeal M. Thermoautotrophicum.[1] Identifiers Symbol … Wikipedia
MCM4 — minichromosome maintenance deficient 4 (S. cerevisiae), also known as MCM4, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is one of the highly conserved mini chromosome maintenance proteins (MCM)… … Wikipedia
MCM6 — MCM6, or minichromosome maintenance deficient 6 gene is one of the highly conserved MCMs that are essential for the initiation of eukaryotic genome replication. The MCM complex consisting of this protein and MCM2, 4 and 7 possesses DNA helicase… … Wikipedia
MCM8 — minichromosome maintenance deficient 8 (S. cerevisiae), also known as MCM8, is a human gene.cite web | title = Entrez Gene: MCM8 MCM8 minichromosome maintenance deficient 8 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… … Wikipedia
MCM7 — minichromosome maintenance deficient 7 (S. cerevisiae), also known as MCM7, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is one of the highly conserved mini chromosome maintenance proteins (MCM)… … Wikipedia
MCM2 — minichromosome maintenance deficient 2, mitotin (S. cerevisiae), also known as MCM2, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is one of the highly conserved mini chromosome maintenance proteins… … Wikipedia
MCM3 — minichromosome maintenance deficient 3 (S. cerevisiae), also known as MCM3, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is one of the highly conserved mini chromosome maintenance proteins (MCM)… … Wikipedia
Origin of replication — The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated.[1] This can either be DNA replication in living organisms such as prokaryotes and eukaryotes, or RNA… … Wikipedia
MCM5 — minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae), also known as MCM5, is a human gene.cite web | title = Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)| url =… … Wikipedia
MCM10 — Minichromosome maintenance complex component 10 Identifiers Symbols MCM10; CNA43; DNA43; MGC126776 External IDs … Wikipedia
