MCM8

MCM8 minichromosome maintenance deficient 8 (S. cerevisiae), also known as MCM8, is a human gene.cite web | title = Entrez Gene: MCM8 MCM8 minichromosome maintenance deficient 8 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84515| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.cite web | title = Entrez Gene: MCM8 MCM8 minichromosome maintenance deficient 8 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84515| accessdate = ]

ee also

*Mini Chromosome Maintenance

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Volkening M, Hoffmann I |title=Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin. |journal=Mol. Cell. Biol. |volume=25 |issue= 4 |pages= 1560-8 |year= 2005 |pmid= 15684404 |doi= 10.1128/MCB.25.4.1560-1568.2005
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Johnson EM, Kinoshita Y, Daniel DC |title=A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. |journal=Nucleic Acids Res. |volume=31 |issue= 11 |pages= 2915-25 |year= 2003 |pmid= 12771218 |doi=
*cite journal | author=Gozuacik D, Chami M, Lagorce D, "et al." |title=Identification and functional characterization of a new member of the human Mcm protein family: hMcm8. |journal=Nucleic Acids Res. |volume=31 |issue= 2 |pages= 570-9 |year= 2003 |pmid= 12527764 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=

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