PC3

PC3
This article is about the cancer cell PC3. For other uses, see PC3 (disambiguation).

PC3 (PC-3) and DU145 human prostate cancer cell lines are the "classical" cell lines of prostatic cancer.[1] PC3 cells have high metastatic potential compared to DU145 cells which have a moderate metastatic potential.[2]

PC3 cell lines were originally derived from advanced androgen independent bone metastasis|metastasized prostate cancer. PC3 have low testosterone-5-alpha reductase activity and express PSA (Prostate Specific Antigen).

References

  1. ^ Alimirah F, Chen J, Basrawala Z, Xin H, Choubey D (April 2006). "DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation". FEBS Lett. 580 (9): 2294–300. doi:10.1016/j.febslet.2006.03.041. PMID 16580667. 
  2. ^ Pulukuri SM, Gondi CS, Lakka SS, et al. (October 2005). "RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo". J. Biol. Chem. 280 (43): 36529–40. doi:10.1074/jbc.M503111200. PMC 1351057. PMID 16127174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1351057. 



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