List of mad scientists

The following is a list of "fictional" mad scientists in cultural sources (literature, movies, comics, etc.). They are split into pre- and post-1945, as the images of mad scientists changed and proliferated in the years following the atomic bombings of Hiroshima and Nagasaki, and the increased role of scientists following World War II.

Before 1945

Literature

* Victor Frankenstein, creator of Frankenstein's monster, in the novel "Frankenstein, or the Modern Prometheus" by Mary Shelley (1818).
* Nathaniel Hawthorne, in his short story "The Birthmark" (1843), shows a scientist who, while perhaps not mad, is certainly overconfident, and whose meddling with nature brings about tragedy.
* The following year, Hawthorne wrote "Rappaccini's Daughter," in which medieval Paduan naturalist Giancomo Rappaccini performs botanical and toxicological experiments on his own daughter.
* Robert Louis Stevenson's "The Strange Case of Dr. Jekyll and Mr. Hyde" (1886) portrays the essentially humane experimenter driven to madness and suicide by the nature of his science.
* Several (but not all) of Jules Verne's novels feature a mad scientist. Some of these are humorous, who fail everything they try; others are shown as rather serious and even dangerous characters. A partial list follows.
** The main characters of "The Chase of the Golden Meteor" ("La Chasse au météore") (1908) are three mad scientists: Dean Forsyth and Sidney Hudelson, rivalling astronomers, and the eccentric inventor Xirdal Zephyrin.
** Thomas Roch in "Facing the Flag" ("Face au drapeau") (1896) is a typical mad scientist in that he doesn't realize his powers are used for evil purposes.
** Captain Nemo, the rich protagonist who builds a submarine appears in two novels "Twenty Thousand Leagues Under the Sea" (1870) and "The Mysterious Island" (1874). However, he appears more as a vigilante, an explorer and a super ingeneer, than a god-playing mad scientist. None of his inventions (not even the Nautilus - who is much more a means to travel and discover the undersea world, than a battle machine) could ever be questioned on any moral ground. Despite being a misanthropic (who still has faith in some good men and who still cares for the underdog), he has no plan to dominate or destroy the world. Furthermore, his research and experiments never involved any living being.
** Arguably, the main character of "Mathias Sandorf" (1885).
** Professor Lidenbrock from "Journey to the Center of the Earth" (1864).
** J. T. Matson (and other characters) in "Barbicane and Co." ("Sans dessus dessous") (1889) and also in "From the Earth to the Moon" (1865) who enjoys making giant cannons.
** "Off on a comet" (orig. title Hector Servadac, 1877) has the astronomer Palmyrin Rosette as an important character.
** "In Search of the Castaways" (1865) has Jacques Paganel, a geographer who becomes involved in the story by accident: he is so forgetful that he's boarded the wrong ship. Nevertheless, he is a very famous scientist in the book, has three lines of titles and three middle names.
** John Hatteras from "The Adventures of Captain Hatteras" ( _fr. Les Aventures du capitaine Hatteras, 1864) can be counted as one as well.
** "Carpathian Castle" (1892) has a mad scientist named "Orfanik".
* H. G. Wells' "The Island of Dr. Moreau" (1896) carried Frankensteinian experimentation a step further with its mad scientist Dr. Moreau, contrasting it with an idyllic 'natural' South Sea island setting. Several film versions were made (such as "The Island of Lost Souls" (1933)).
* The Harold MacGrath 1920 novel "The Drums of Jeopardy" had a Russian mad scientist named "Boris Karlov" reported to be the source for the stage name adopted by actor Boris Karloff.
* Dr. Herbert West, a Frankenstein-like doctor obsessed with bringing the dead back to life, in H. P. Lovecraft's novella "Herbert West, Reanimator" (1922).
* Griffin, from The Invisible Man (1897) by H.G. Wells. Griffin discovers the secret of invisibility, but the process sends him into murderous insanity.
* Vladimir Ipat'evich Persikov, a specialist in reptiles, in The Fatal Eggs (1924) by Mikhail Bulgakov.
* Philip Philippovich Preobrazhensky who implants human testicles and pituitary gland into a stray dog named Sharik, in Heart of a Dog (1925) by Mikhail Bulgakov.
* Phor Tak, the discoverer of invisibility in Edgar Rice Burroughs' 1930 science-fiction novel, "A Fighting Man of Mars".
* Dr Rance Mandarin, a.k.a. Doctor Death, from the novels "12 Must Die", "The Gray Creatures" and "The Shriveling Murders" which appeared in three issues of the pulp magazine "Doctor Death" in 1935.

Movies

* "The Cabinet of Dr. Caligari" (1919) is a silent film featuring the mad hypnotic doctor and his sleepwalking assistant.
* Dr. Mabuse, most famous from the films made about him by Fritz Lang
* C. A. Rotwang in Fritz Lang's "Metropolis" (1927).
* Dr. Frankenstein in several movie versions.
* Dr. Jack Griffin, in the film "The Invisible Man" (1933), adapted from the Wells novel.
* Dr. Janos Rukh, in the film "The Invisible Ray" (1936). Dr. Rukh discovers a radioactive ray that cures blindness but causes him to develop a murderous paranoid rage against other scientists, whom he accuses of stealing his discovery.
* Dr. Thorkel, in the film "Dr. Cyclops" (1940). Dr. Thorkel shrinks opponents of his unorthodox experimentation with radium.
* Armand Tesla=Nikola Tesla, Bela Lugosi plays Romanian scientist/vampire in "The Return of the Vampire" (1944)

After 1945

Novels

* Dr. Adam Burkhardt, in the Frank Peretti novel "Monster", who mutates a chimpanzee to the point where it grows into a bigfoot-like creature, after which it escapes the lab and gruesomely kills several people.
* Dr. Jacob Burroughs, Colonel, A.U.S. from Robert A. Heinlein's "The Number of the Beast" (1980) (Although Heinlein used the term "Mad Scientist" to describe him, he does not exhibit many of the characteristics.)
* The unnamed narrator in Thomas Ligotti's short story "The Chymist".
* Domontor the Demented, in the Dave Morris and Oliver Johnson gamebook "Temple of Flame".
* Dr. Hugo Grief from the Alex Rider book "Point Blanc".
* Various parodies in Terry Pratchett stories, including Hugo Lavish in "Making Money" and Igor the manservant.
* Xavier Mace, a recurring adversary in a 1990s series of "Tom Swift, Jr." books.
* "The Mad Scientists' Club": a book series that portrayed seven oddball teens who are actually good scientists and brave adventurers rather than wacky science freaks
* Dr. Ignacio Metz, who did unorthodox experiments with dolphin uplift in David Brin's "Startide Rising".
* Mole, the genius inventor and hunter of Nazis in the "Burke" series of novels by Andrew Vachss.
* Characters from the "James Bond" series of novels:
** Dr. Julius No from "Dr. No".
** Dr. Anton Murik in "Licence Renewed".
* Dr. Roger Nordhagen, a plastic surgeon with something nasty in the basement, in Thomas Tessier's novel "Finishing Touches".
* The Horrible Math Teacher in the "GrailQuest" gamebooks.
* John Roe O'Neill, in the Frank Herbert novel "The White Plague".
* Dr. Fabian Rosten, in "High Times".
* De Selby, an eccentric Irish philosopher and scientist in "The Third Policeman" and "The Dalkey Archive" by Flann O'Brien.
* Vergil Ulam, in the Greg Bear novel "Blood Music".
* Dr. Lazlo Zand, from the "Robotech" novels by Jack Mckinney.
* Crake from "Oryx and Crake" by Margaret Atwood.
* Doctor Impossible, from "Soon I Will Be Invincible" by Austin Grossman.
* The Doctor, from "Ecstasia" and "Primavera" by Francesca Lia Block.
* Lois Wilson, from "Brainchild" by Andrew Neiderman.
* Melvin Dobbs, from "Resurrection Dreams" by Richard Laymon.
* Jamie Angelo, from "Beauty" by Brian D'Amato.
* Dr. Victor Beaufort and Dr. Griffin, from "The Jigsaw Woman" by Kim Antieau.
* Dr. Wade Ormont, from L. Sprague de Camp's short story "Judgment Day".

Movies

* Dr. Strangelove, the title character (1964)
* Dr. Benway in "Naked Lunch" (1991)
* Ernst Stavro Blofeld from James Bond, head of SPECTRE.
* Professor Ned Brainard "The Absent-Minded Professor" (1961)
* Dr. Emmett Brown in the "Back to the Future" trilogy
* Dr. Seth Brundle in David Cronenberg's remake of "The Fly"
* The Skeksis skekTek in The Dark Crystal [1982]
* Dr. Eldon Tyrell in "Blade Runner" (1982)
* Sebastian Caine, in "Hollow Man" (2000)
* Max Cohen, in "Pi" (1998)
* Sir August DeWynter, in "The Avengers" (1998)
* Kevin Dornwinkle, in "Invisible Maniac" (1990)
* Dr. Durand Durand, in "Barbarella" (1968)
* Elizabeth, from "Wicked Science"
* Dr. Evil, nemesis of Austin Powers
* Dr. Finkelstein in "The Nightmare Before Christmas" (1993)
* Dr. Otto Frank, in "Monstrosity" (1964)
* Dr. Victor Frankenstein (in the film versions, at least)
* Dr. Elaine Frederick, in "Flesh Feast" (1970)
* Dr. Frank N. Furter, in "The Rocky Horror Picture Show" (1975)
* Cosmo and Nation McKinley, in "Shock Treatment" (1981)
* Tania Frankenstein, in "Lady Frankenstein" (1971)
* Dr. Maria Frankenstein, in "Jesse James Meets Frankenstein's Daughter" (1966)
* Professor Foot in "Help!" (1964)
* The protagonists of "Ghostbusters"
* Dr. Charles Girard, in "Terror Is a Man" (1959)
* Dr. Gulk, in "Supersonic Man" (1979)
* Dr. Susan Harris, in "Invasion of the Bee Girls" (1973)
* Dr. Paul Holliston, in "Embryo" (1976)
* Professor Julius Kelp in "The Nutty Professor" (1963)
* Professor Sherman Klump from "The Nutty Professor (1996 film)" and ""
* Dr. Kobras, in "Puma Man" (1980)
* Baron von Kratzmar in "Adele Hasn't Had Her Dinner Yet" (1977)
* Krank, and the doctor who made him, in "The City of Lost Children" (1995)
* Doctor Kraspin, in "The Humanoid" (1979)
* Dr. Kurt Leopold, "Zaat" (1972)
* Dr. Emilio Lizardo, in "The Adventures of Buckaroo Banzai Across the 8th Dimension" (1984)
* Dr. Logan - "Day of the Dead" (nicknamed "Dr. Frankenstein")
* Dr. Lorca, in the film "Mad Doctor of Blood Island" (1968)
* Dr. Arliss Loveless, in "Wild Wild West" (1999)
* Professor Mason, in "Death Dimension" (1978)
* Dr. Mifune, in Terror of Mechagodzilla
* Dr. Edward Morbius, in "Forbidden Planet" (1956)
* Edward Nigma, aka The Riddler, in "Batman Forever"
* Jason Woodrue in "Batman and Robin" (1997)
* Dr. No, and various other characters from the "James Bond" series of films
* Professor Nolter, in "The Mutations" (1973)
* J. Frank Parnell, in "Repo Man" (1984)
* The Abominable Dr. Phibes ("Vincent Price") in the series "The Abominable Dr. Phibes"
* Philo in "UHF" (While he is not exactly mad, he is absent-minded, and does work and live in a lab/workshop.)
* Dr. Hans Reinhardt, in "The Black Hole" (1979)
* Michael Sharrington, in "Graveyard of Horror" (1971)
* Dr. Tolian Soran from the "Star Trek" film "Star Trek Generations"
* Dr. Carl Stoner, in "Ssssss" (1973)
* Syndrome/Buddy Pine, in "The Incredibles" (2004)
* Dr. Jane Tiptree in "Carnosaur (film)" (1993)
* Dr. Sy N. Tist, from the "Mad Scientist" series
* Dr. Totenkopf, in "Sky Captain and the World of Tomorrow" (2004)
* Dr. Richard Benjamin Vannacutt from "House on Haunted Hill" (1999)
* Dr. Eric Vornoff (Bela Lugosi) in "Bride of the Monster"
* Dr. Calvin Weber in "Blast from the Past" (1997)
* Professor Wendland, in "Superargo" (1968)
* Dr. Gediman, in "" (1997)
* Dr. Herbert West, in "Re-Animator" (1985)
* Nathaniel Pickman Wingate in "Kamillions" (1989)
* Doctor Rush, the female scientist from "Black Sheep (2007 film)"
* Dr. Horrible, in "Dr. Horrible's Sing-Along Blog" (2008)

Television series

* Dr. Walter Bishop, from "Fringe"
* Dr. Bunsen Honeydew from "The Muppet Show"
* Jha'Dur (AKA Deathwalker), from the "Babylon 5" episode "Deathwalker"
* Professor Maggie Walsh, from the TV series "Buffy the Vampire Slayer"
* Dr. Crell Moset , from the TV series "Star Trek Voyager"
* Dr. Clayton Forrester, from "Mystery Science Theater 3000", named after the hero scientist in the 1953 film "The War of the Worlds"
* Dr. Laurence Erhardt, from "Mystery Science Theater 3000". Appeared in the initial locally broadcast season, and in the first national season along with Dr. Clayton Forrester.
* Pearl Forrester from Mystery Science Theater 3000. The mother of Clayton, she took up mad science and resumed the experiments to get revenge on the Satellite of Love crew although she was unaccredited.
* Dr. Yes, and various other parodic characters in "Get Smart"
* Dr. Miguelito Loveless, in the 1960s series "The Wild Wild West"
* Dr. Momus Alexander Morgus from "Morgus Presents!"
* Johann Wilhelm Möbius in Dürrenmatt's satiric drama "The Physicists" (1962)
* Namtar, from "Farscape"
* Dr. Chaotica from the "Bride of Chaotica" episode in ""
* Dr. Paul Museveni from Andromeda
* Davros, the Rani, Doctor Mehendri Solon, Taren Capel, Professor Zaroff and Lazarus, from "Doctor Who"
* Degra, from ""
* Dr. Arik Soong, from ""
* Dr. Phlox (Mirror Universe version), from ""
* The Angry Scientist from "Sheep in the Big City"
* Dr. Sparrow from "Angel"
* Professor Chagrijn from "Bassie and Adriaan"
* Dr. Julia Hoffman from "Dark Shadows"
* Dr. Ignatius Faust Fear II from "The Mysterious Lab of Dr. Fear" horror show from Enid Oklahoma"
* Dr. TwoBrains from "WordGirl
* Dr. Donald Baxter from "Curse of The Blood of The Lizard of Doom" who attempts to find a cure for the common burn, but ends up turning people into lizard monsters. (2001)

Cartoon

* The Professor, from the cartoon series "Felix the Cat"
* The Evil Scientist from "Looney Tunes"
* Corey Allan Smith
* Dr. Hess from the manga/anime "Saber Marionette J"
* Dr. Agasa from the manga/anime "Detective Conan"
* Doctor Arkeville, from the cartoon series (but not the comic or toyline) "Transformers"
* Bighead from The Ambiguously Gay Duo
* Dr. Blight, a female mad scientist specialising in genetic engineering and air pollution, from "Captain Planet and the Planeteers"
* Dr. Animo from "Ben 10"
* The Brain, from "Animaniacs" and "Pinky and the Brain"
* Dr. Reginald Bushroot and Elmo Sputterspark from Darkwing Duck
* Hector Con Carne and Major Dr. Ghastly, from "Evil Con Carne"
* rotcoD daM, from the cartoon series "Sinbad the Sailor"
* Dexter and Mandark, of "Dexter's Laboratory"
* Dr. Drakken (a.k.a. Drew Lipsky), DNAmy (a.k.a. Amy Hall), and Professor Dementor, from the TV series "Kim Possible"
* Dantalion, also a Crimson Lord in "Shakugan no Shana"
* Dr. Eyepatch from "The Super Milk-chan Show"
* Professor Hubert Farnsworth from the cartoon series "Futurama"
* Professor Fingers, in "DoDo, The Kid from Outer Space" (1965)
* Carl Foutley (aspiring), on "As Told By Ginger"
* Professor Frink from "The Simpsons"
* Dr. Putrid T. Gangreen from the cartoon series "Attack of the Killer Tomatoes" (1994)
* Dr. Gero, Dr. Myū and Dr. Wheelo from "Dragonball Z"
* Newton Gimmick in "The Adventures of Teddy Ruxpin"
* Rear Admiral Ginias Sahalin of ""
* Hugo A Go Go, from the cartoon series "Batfink"
* Professor Goatsbeard (Dutch original Joachim Sickbock), an anthropomorphic goat, from the Tom Puss/Oliver B. Bumble cartoon series. A statue of the mad scientist can be seen in Rotterdam. [http://www.cirque.nl/sculptur/all/Monu3.html]
* Professor Grotalent from the French comics/cartoon "Spiff and Hercules".
* Washu Hakubi in the anime series" Tenchi Muyo!"
* Dr. Hell from Go Nagai's manga and anime "Mazinger Z"
* Fritz Huhnmorder, from the action figure stop-motion television show, "Robot Chicken"
* Head Commander Gendo Ikari in "Neon Genesis Evangelion"
* Dr. Katsuhito Stingray from Bubblegum Crisis Tokyo 2040"
* Dr. J, Professor G, Doktor S, Instructor H, and Master O from the anime "Gundam Wing"
* Dr. Jumba Jookiba, from the "Lilo & Stitch" cartoons and movies
* Professor Moshimo and Dr. Kamikazi, from "Robotboy"
* Dr. Muraki Kazutaka, whose interest in (and applications of) genetics, cloning, and anatomy in general stem from decidedly less than harmless intentions. He's from the anime " Yami no Matsuei"
* Mayuri Kurotsuchi and Szayel Aporro Granz from "Bleach"
* Kururu from "Keroro Gunsou"
* Eiri Masami from "Serial Experiments Lain"
* Vlad Masters/Vlad Plasmius from "Danny Phantom"
* Professor Membrane from "Invader Zim"
* Dr. Viper from ""
* Dr. Mephesto from "South Park"
* Ichiro "Icchan" Mihara from "Angelic Layer"
* Mojo Jojo, Professor Utonium, and Dick Hardly from "The Powerpuff Girls"
* Dr. Desty Nova from the anime/manga series "Battle Angel Alita", who used Nanotechnology to try to overcome the human Karma
* Jimmy Neutron, Professor Finbarr Calamitous, and Doctor Sydney Orville Moist, from
* Orochimaru, from the manga/anime "Naruto". Note that while he is not actually a scientist, he does experiment with justsu in a similar fashion.
* Mr. Paulson, from "Teamo Supremo". However, the real mad scientist of the series was an occasional villain named Dr. Droid, who constructed robot look-alikes of everyone because he believed robots to be superior.
* Professor von Proton from "The Big Knights", described as "that discraced scientist from village Borodzo". Inventor of the Protonosphere (a time travel machine), and Proton-Power a highly unstable method of power generation fueled by "freely available porcine agricultural by-product".
* Simon Bar Sinister, from the "Underdog" cartoon (1964)
* Dr. Slump from "Dr. Slump"
* Dr. Mashirito from "Dr. Slump"
* Professor Squarkencluck, from the cartoon "Dangermouse"
* Baxter Stockman and occasionally Donatello and Leatherhead from the "Teenage Mutant Ninja Turtles"
* Kaolla Su from the manga/anime Love Hina
* Tarantulas, from the "Beast Wars" animated series
* Professor Tomoe from the manga/anime series "Sailor Moon"
* Shou Tucker, Zolf Kimblee, and others in "Fullmetal Alchemist"
* Dr. Nora Wakeman, from the TV series "My Life as a Teenage Robot"
* Dr. Weird from "Aqua Teen Hunger Force"
* Phineas J. Whoopee from Tennessee Tuxedo
* Wheeljack, an autobot from the Transformers
* Dr. Zin, from the "Jonny Quest" cartoon series
* Urpgor, from the cartoon series "The Dreamstone"
* Voltaire, Doctor B & Doctor K from the manga/anime Beyblade
* Tracy McBean, from the cartoon of the same name
* Dr. Benjamin Boris Zachary Karbunkle from Biker Mice from Mars
* Muffy Pepperidge from Totally Spies (episode 111)
* Mary and Susan Test from Johnny Test cartoon Series
* Doctor Thaddeus Venture, from The Venture Bros.
* Doctor Colossus from "The Simpsons"
*""The Doctor"" from the manga and "OVA" "Hellsing". His name is unknown and he is simply referred to as "DOC".
* Dr. Harleen Quinzel (aka "Harley Quinn"), a mad psychiatrist turned villain from "".
* Doctor Hogback from the manga/anime series One Piece
* Sheldon J. Plankton from the cartoon series SpongeBob SquarePants

Comics

* Professor Shelley and the Necro-Nazis, from John Michael McCarthy's "Cadavera"
* Doctor Doom, from Marvel Comics, arch-enemy of the Fantastic Four
* Mister Sinister, from Marvel comics
* Lex Luthor, from DC Comics, arch-enemy of Superman
* Doctor Sivana from DC Comics
* Norman Osborn (The Green Goblin), Otto Octavius (Doctor Octopus), and Curt Connors (The Lizard) in "Spider-Man", went mad and became evil after an experiment mutated or altered them
* Doctor Jonas Harrow, an enemy of Spider-Man
* Egghead and Dr. Henry Pym from Marvel comics
* The Mandarin from Marvel comics
* Riff, Dr. Catherine Crabtree, and Dr. Irving Schlock, from "Sluggy Freelance".
* Dr. August Hopper a.k.a. The Locust, and "Forge (comics)" from the "X-Men" comics
* Dr. Cedric Rawlings from the "Captain America" comics
* Dr. Light, enemy of the Teen Titans
* Doctor Light (Kimiyo Hoshi), a grudgingly heroic female version of the above introduced during "Crisis on Infinite Earths"
* Baron Karza from the Micronauts comic book (Marvel)
* Gyro Gearloose from the Scrooge McDuck universe
* Dr. Weekday and Dr. Saruta from the Tezuka manga "Phoenix" series
* Mad Scientist is Monster in My Pocket #39. In the comicbook, he is clearly Dr. Jekyll and Mr. Hyde, though in the first issue, drawn by Ernie Colon he seems to be a transitional version of the two, and looking more like he came from the eighteenth century than the nineteenth. Both of these were corrected by Gil Kane the following issue. In it and subsequent issues, written by Dwayne McDuffie, he would frequently be force-fed his potion as a significant plot complication.
* Professor Cuthbert Calculus (Professeur Tryphon Tournesol) from "The Adventures of Tintin"
* Prof. Septimus in Blake and Mortimer's "The Yellow Mark"
* Professor Miloch Georgevitch in Blake and Mortimer's "The Diabolical Trap"
* The Count of Champignac and Zorglub from "Spirou et Fantasio"
* Baron Klaus Wulfenbach, Agatha Heterodyne, and other "Sparks", from Phil and Kaja Foglio's "Girl Genius" comics
* Dr. Helen Narbon, Helen Beta Narbon, Lupin "Wolf" Madblood, and others in the webcomic "Narbonic"
* Dr. Vanessa Leather, Monster-Maker, in Elizabeth Watasin's "Charm School"
* Casey and Andy from the webcomic "Casey and Andy"
* Tedd Verres and Dr. Germahn, from the webcomic "El Goonish Shive"
* Dr. Otto Bonn, from the webcomic "The Polymer City Chronicles"
* Dr. Virgil Haas, and other victims of Science Related Memetic Disorder, from the webcomic "A Miracle of Science". The lead character, Agent Benjamin Prester of the Vorstellen Police, is a "recovered" mad scientist who works investigating and preventing mad-science related crimes.
* Nick Wellington and Professor Otto Wisebottom, from the webcomic "General Protection Fault"
* Gav Van Darin, Danny Hua, King Luca, and Suzy Gee, from the webcomic "Nukees"
* Dr. Von Richter, the chief villain of the Argentine comic book, Cybersix, and its various adaptations
* Bernie, from the comic strip "Doonesbury"
* T.O. Morrow, enemy of the Justice League.
* Frederick Willheim creator of cyborg gorilla Cy-Gor, a Spawn villain.
* Kevyn Andreyasn, from the webcomic "Schlock Mercenary"
* Franjinha, from Monica's Gang, a popular Brazilian series.
* Nearly the entire cast of Mad About U.
* Hugo Strange
* Dr. Jonathan Crane (Scarecrow)
* Pamela Isley (Poison Ivy)
* Victor Fries (Mr. Freeze)
* Kirk Langstrom (Man-Bat)
* Doctor Emile Dorian
* Doctor Milo
* Professor Barabas, from the comic books series "Spike and Suzy"
* Wheeljack, from "Transformers"
* Barry Ween from "The Adventures of Barry Ween Boy Genius"
* Erwin "Pee Wee" Talon, from Fred Perry's "Gold Digger"

Video games

*Rodyle from "Tales of Symphonia"
*Izuka from ""
*Doctor Albert W. Wily, from the video game series "Mega Man"
* Gate, a Reploid Scientist from Mega Man X6.
*Doctor Weil, a Neo Arcadian in Mega Man Zero series
*Doctor Hans Ubermann, from the "Indiana Jones and the Fate of Atlantis" adventure game (1992)
*Doctor Neo Cortex, alongside his colleagues Doctor N. Gin, Doctor Nitrus Brio and Doctor Nefarious Tropy from the "Crash Bandicoot" game series.
*Professor Curien and Goldman, from The House Of The Dead series
*Doctor Synthesis, from Gahan Wilson's The Ultimate Haunted House
*Dr. Caulder, from
*Doctor Fred Edison, from adventure games "Maniac Mansion" and "Day of the Tentacle"
*Professor Gerald Robotnik, Doctor Eggman's grandfather
*Doctor Eggman (a.k.a. Doctor Robotnik), from the "Sonic the Hedgehog" video game series
*Dr. Nefarious from
*Doctor Brain, from the educative video games "Island of Doctor Brain", "Castle of Doctor Brain", "The Lost Mind of Doctor Brain" and "The Time Warp of Doctor Brain"
*Doctor Proton, from "Duke Nukem 1"
*Doctor Gregor Hoffman from ""
*Doctor Malcolm Betruger, from "Doom 3"
*Doctor William Birkin, from "Resident Evil 2"
*Doctor Killjoy, owner and main physician of 'Carnate Institution for the Alienated', whose treatment methods were drastic and lethal, including lobotomy, dismembernment and electro-shock therapy. Appears in "The Suffering"
*Doctor Muto, titular character of "Dr. Muto"
*Professor Burnital, Dr. Muto's arch-nemesis
*Doctor Baldhead, from the "Guilty Gear" series
*Doctor Bomb, from platform game "Bravoman"
*Doctor Wallace Breen, Black Mesa Administrator turned puppet dictator of Earth, "Half-Life 2".
*Doctor Sludge Vohaul from the Space Quest series.
*Doctor Schabbs and Otto Giftmacher from Wolfenstein 3D.
*Doctor Edward W. Johansson from XIII
*Andross, from game series "Star Fox"
*Professor E. Gadd, from the Mario Games.
*Doctor Ironstein, from the "Flight of the Amazon Queen" adventure game (1995)
*Doctor Ignatio Mobius, from the "Command & Conquer" series.
*Guildenstern, a Genma Scientist from the Onimusha series
*Doctor Lugae from "Final Fantasy IV"
* Cid del Norte Marguez from "Final Fantasy VI".
*Professor Hojo from "Final Fantasy VII".
*Dr. Cidolfus Demen Bunansa from "Final Fantasy XII".
*Vexen from "".
*Doctor Knarf, from the Sony PlayStation 3D platform game, Jersey Devil.
*Doctor Boskonovitch, from Tekken
*Doctor Jacob Crow, creator of the Timesplitters from
*Bishop Mandible from Loom
*Henry Stauf from The 7th Guest
*Doctor Willard from Tomb Raider 3
*Doctor Cranium from
*Doctor Pretorius / Dr. Mobius (the same person) from
*Garlen from the Klonoa series
*Doctor (George Wilhelm) Krieger from the Far Cry series
*Doctor Crygor from the "WarioWare" series of games
*Baron K. Roolenstein from ""
*Doctor Exavolt from
*Doctor Riptide from In Search of Dr. Riptide
*Cranky Kong from Donkey Kong 64
*Professor Elvin Atombender from Impossible Mission
*Doctor Caligosto Loboto from Psychonauts
*Doctor Vu from Sim City 4
*Doctor Kiln from Clayfighter 63 1/3
*Dr. Bad-Boon from Super Monkey Ball 2
*Doctor Beruga from Terranigma
*In Bioshock, Dr Tennenbaum, Dr Suchong, and Dr Steinman.
* Doctor Drago Petrovich Madnar in ""

Toys

* Dr. X, from "Action Man"
* Dr. Ein-O, from "Smart Boxes". He is directly based on Albert Einstein.
* Dr. Mindbender, from the cartoon, comic, and toyline "G.I. Joe"
* Dr. Sy N Tist, from Mad Scientist by Mattel
* Mutran, from "BIONICLE"

Audio drama

* Dr. Marlin Mazoola, from the adventures of "Jack Flanders"
* Professor Nebulous, the head of KENT in Nebulous
* Dr. Floyd J. Floyd Jr., from the "The Radio Adventures of Dr. Floyd"

Opera

* Soprano 1 in "Facing Goya"
* Tenor in "Facing Goya"