Radicicol

Radicicol: Radicicol

IUPAC name

(1aR,2E,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione

Identifiers

CAS number 12772-57-5 ^Y

PubChem 6323491

ChemSpider 16735913^Y

ChEMBL CHEMBL453386

Jmol-3D images Image 1

SMILES

O=C1\C=C\C=C/C3OC3CC(C)OC(=O)c2c(O)cc(O)c(Cl)c2C1

InChI

InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-^Y
Key: WYZWZEOGROVVHK-HZDAAVBUSA-N^Y

Properties

Molecular formula C₁₈H₁₇ClO₆

Molar mass 364.78 g mol⁻¹

Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Infobox references

Radicicol, also known as monorden, is a natural product that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.

Further reading

Winssinger N, Barluanga S (January 2005). "Chemistry and biology of resorcylic acid lactones". Chem Commun 13 (1): 22–36. doi:10.1049/b610344h. PMC 2529160. PMID 17277252. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2529160. Review of the chemistry and biology of resorcylic acid lactones, including radicicol.

Categories:
Epoxides
Macrolides
Halogen-containing natural products
Biochemistry stubs

Radicicol

IUPAC name (1aR,2E,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
Identifiers
CAS number	12772-57-5 ^Y
PubChem	6323491
ChemSpider	16735913^Y
ChEMBL	CHEMBL453386
Jmol-3D images	Image 1
SMILES O=C1\C=C\C=C/C3OC3CC(C)OC(=O)c2c(O)cc(O)c(Cl)c2C1
InChI InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-^Y Key: WYZWZEOGROVVHK-HZDAAVBUSA-N^Y
Properties
Molecular formula	C₁₈H₁₇ClO₆
Molar mass	364.78 g mol⁻¹
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

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Look at other dictionaries:

radicicol — radicícol adj. m., pl. radicícoli; f. sg. radicícolă, pl. radicícole Trimis de siveco, 10.08.2004. Sursa: Dicţionar ortografic RADICÍCOL, Ă adj. 1. Care creşte pe rădăcini. 2. Care trăieşte în simbioză cu rădăcinile. [< … Dicționar Român
radicicol — noun A particular natural product that binds to heat shock protein 90 and alters its function. Syn: monorden … Wiktionary
HSP90 — Das molekulare Chaperon (Protein) Hsp90 ist mit 1–2 % des gesamten löslichen Zellproteins eines der am häufigsten vorkommenden Proteine in der Zelle. Es kommt ubiquitär in Eubakterien und allen Klassen von Eukaryoten vor. In Archaeen scheint es… … Deutsch Wikipedia
Hsp90 — Das molekulare Chaperon Hsp90 ist mit 1–2 % des gesamten löslichen Zellproteins eines der am häufigsten vorkommenden Proteine in der Zelle. Es kommt ubiquitär in Eubakterien und allen Klassen von Eukaryoten vor. In Archaeen scheint es jedoch … Deutsch Wikipedia
List of biomolecules — This page aims to list articles on Wikipedia that describe particular biomolecules or types of biomolecules.This list is not necessarily complete or up to date if you see an article that should be here but isn t (or one that shouldn t be here but … Wikipedia
Hsp90 — Pfam box Symbol = Hsp90 NTD Name = Hsp90, N terminal domain width = 270px caption = Solid ribbon model of the yeast Hsp90 dimer (α helices = red, β sheets = cyan, loops = grey) in complex with ATP (red stick diagram) based on PDB|2CG9. Pfam=… … Wikipedia
Dihydrolipoyl transacetylase — dihydrolipoyllysine residue acetyltransferase Atomic structure of a single subunit of dihydrolipoyl transacetylase from Azotobacter vinelandii that makes up the structural core of the pyruvate dehydrogenase multienzyme complex.[1] … Wikipedia
Estrogen receptor alpha — Estrogen receptor 1 PDB rendering based on 1a52 … Wikipedia
PDK3 — Pyruvate dehydrogenase kinase, isozyme 3 PDB rendering based on 1y8n … Wikipedia
Liste d'antibiotiques — Cette liste répertorie les antibiotiques. Formule chimique Nom Masse molaire Numéro CAS EINECS PubChem C8H12N2O3S acide 6 aminopenicillanique 216.25748 551 16 6 … Wikipédia en Français

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Radicicol

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Radicicol

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