Methylase

A methylase is an enzyme that attaches a methyl group to a molecule.

These are found in prokaryotes and eukaryotes. Bacteria use methylase to differentiate between foreign genetic material and their own, thus protecting their DNA from their own immune system. By placing a methyl group on a base of the recognition site of a restriction endonuclease, methylases prevent the enzyme from cleaving the bacterial DNA. ^[1]

There are methylases that can methylate DNA, RNA, proteins, or small molecules, for example, DNA methyltransferase, which methylates cytosine residues and adenine residues in DNA. A new relevant example is a methylase that alters the ribosomal RNA binding site of the antibiotic linezolid and causes cross-resistance to other antibiotics which act on the ribosomal RNA. Plasmid vectors capable of transmitting this gene are a cause of potentially dangerous cross resistance.^{[2] [3]}

See also

• Demethylase

References

1. ^ Nelson Biology 12 (2003)
2. ^ Morales G, Clin Infect Dis 2010;50:821-5
3. ^ RC Moellering N Engl J Med 2010; 363: 2377-9

This transferase article is a stub. You can help Wikipedia by expanding it.v · Categories: Transferase stubs EC 2.1.1 Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР John Lowe Mk 4/Mk 40 Folding-Fin Aerial Rocket Look at other dictionaries: methylase — methylase. См. метилаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь. Méthylase — La Méthylase est une enzyme qui attache un groupe méthyle à une molécule. On la retrouve dans les procaryotes et les eucaryotes. Les bactéries utilisent un méthyle afin de distinguer leur propre génome du matériel génétique étranger. De ce fait,… …   Wikipédia en Français methylase — noun Date: circa 1952 an enzyme that catalyzes methylation (as of RNA or DNA) …   New Collegiate Dictionary methylase — noun Any of several enzymes that catalyze methylation, especially of nucleic acids …   Wiktionary Methylase — Me|thy|la|se [↑ Methyl u. ↑ ase], die; , n: svw. ↑ Methyltransferase …   Universal-Lexikon methylase — meth·yl·ase meth ə .lās, .lāz n an enzyme (as DNA methyltransferase) that catalyzes methylation (as of RNA or DNA) …   Medical dictionary methylase — meth·yl·ase …   English syllables methylase — ˈmethəˌlās, āz noun ( s) Etymology: methyl + ase : an enzyme that catalyzes methylation (as of RNA or DNA) …   Useful english dictionary Dam (methylase) — DAM methylase (DNA adenine methylase) is an enzyme that adds a methyl group to the adenine of the sequence 5 GATC 3 in newly synthesized DNA.[1][2] Immediately after DNA synthesis, the daughter strand remains unmethylated for a short time.[3] …   Wikipedia dam methylase — An enzyme responsible for the methylation of adenine residues in specific sequences. SYN: deoxyadenosine methylase …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”