Lymphocyte cytosolic protein 2

Lymphocyte cytosolic protein 2

Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa), also known as LCP2 or SLP-76, is a gene which encodes a signal transducing adaptor protein.cite web | title = Entrez Gene: LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)| url =| accessdate = ]

section_title =
summary_text = SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.cite web | title = Entrez Gene: LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Jackman JK, Motto DG, Sun Q, "et al." |title=Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7029–32 |year= 1995 |pmid= 7706237 |doi=
*cite journal | author=Sunden SL, Carr LL, Clements JL, "et al." |title=Polymorphism in and localization of the gene LCP2 (SLP-76) to chromosome 5q33.1-qter. |journal=Genomics |volume=35 |issue= 1 |pages= 269–70 |year= 1996 |pmid= 8661136 |doi= 10.1006/geno.1996.0354
*cite journal | author=Motto DG, Ross SE, Wu J, "et al." |title=Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. |journal=J. Exp. Med. |volume=183 |issue= 4 |pages= 1937–43 |year= 1996 |pmid= 8666952 |doi=
*cite journal | author=Wardenburg JB, Fu C, Jackman JK, "et al." |title=Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 19641–4 |year= 1996 |pmid= 8702662 |doi=
*cite journal | author=Onodera H, Motto DG, Koretzky GA, Rothstein DM |title=Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22225–30 |year= 1996 |pmid= 8703037 |doi=
*cite journal | author=Mizuno K, Katagiri T, Hasegawa K, "et al." |title=Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells. |journal=J. Exp. Med. |volume=184 |issue= 2 |pages= 457–63 |year= 1996 |pmid= 8760799 |doi=
*cite journal | author=Raab M, da Silva AJ, Findell PR, Rudd CE |title=Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. |journal=Immunity |volume=6 |issue= 2 |pages= 155–64 |year= 1997 |pmid= 9047237 |doi=
*cite journal | author=Musci MA, Hendricks-Taylor LR, Motto DG, "et al." |title=Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 11674–7 |year= 1997 |pmid= 9115214 |doi=
*cite journal | author=da Silva AJ, Li Z, de Vera C, "et al." |title=Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 14 |pages= 7493–8 |year= 1997 |pmid= 9207119 |doi=
*cite journal | author=Fu C, Chan AC |title=Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27362–8 |year= 1997 |pmid= 9341187 |doi=
*cite journal | author=Zhang W, Sloan-Lancaster J, Kitchen J, "et al." |title=LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. |journal=Cell |volume=92 |issue= 1 |pages= 83–92 |year= 1998 |pmid= 9489702 |doi=
*cite journal | author=Fu C, Turck CW, Kurosaki T, Chan AC |title=BLNK: a central linker protein in B cell activation. |journal=Immunity |volume=9 |issue= 1 |pages= 93–103 |year= 1998 |pmid= 9697839 |doi=
*cite journal | author=Chu J, Liu Y, Koretzky GA, Durden DL |title=SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling. |journal=Blood |volume=92 |issue= 5 |pages= 1697–706 |year= 1998 |pmid= 9716598 |doi=
*cite journal | author=Binstadt BA, Billadeau DD, Jevremović D, "et al." |title=SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27518–23 |year= 1998 |pmid= 9765283 |doi=
*cite journal | author=Liu SK, Fang N, Koretzky GA, McGlade CJ |title=The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. |journal=Curr. Biol. |volume=9 |issue= 2 |pages= 67–75 |year= 1999 |pmid= 10021361 |doi=
*cite journal | author=Gross BS, Lee JR, Clements JL, "et al." |title=Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5963–71 |year= 1999 |pmid= 10026222 |doi=
*cite journal | author=Erdreich-Epstein A, Liu M, Kant AM, "et al." |title=Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages. |journal=J. Leukoc. Biol. |volume=65 |issue= 4 |pages= 523–34 |year= 1999 |pmid= 10204582 |doi=
*cite journal | author=Asada H, Ishii N, Sasaki Y, "et al." |title=Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. |journal=J. Exp. Med. |volume=189 |issue= 9 |pages= 1383–90 |year= 1999 |pmid= 10224278 |doi=
*cite journal | author=Wunderlich L, Faragó A, Downward J, Buday L |title=Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes. |journal=Eur. J. Immunol. |volume=29 |issue= 4 |pages= 1068–75 |year= 1999 |pmid= 10229072 |doi=
*cite journal | author=Gross BS, Melford SK, Watson SP |title=Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets. |journal=Eur. J. Biochem. |volume=263 |issue= 3 |pages= 612–23 |year= 1999 |pmid= 10469124 |doi=

ee also

* T cell activation

External links


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