LCP1

LCP1

Lymphocyte cytosolic protein 1 (L-plastin), also known as LCP1, is a human gene.

PBB_Summary
section_title =
summary_text = Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.cite web | title = Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3936| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Namba Y, Ito M, Zu Y, "et al." |title=Human T cell L-plastin bundles actin filaments in a calcium-dependent manner. |journal=J. Biochem. |volume=112 |issue= 4 |pages= 503–7 |year= 1993 |pmid= 1491005 |doi=
*cite journal | author=Zu Y, Kohno M, Kubota I, "et al." |title=Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells. |journal=Biochemistry |volume=29 |issue= 4 |pages= 1055–62 |year= 1990 |pmid= 2111166 |doi=
*cite journal | author=Zu YL, Shigesada K, Nishida E, "et al." |title=65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites. |journal=Biochemistry |volume=29 |issue= 36 |pages= 8319–24 |year= 1991 |pmid= 2252891 |doi=
*cite journal | author=Lin CS, Aebersold RH, Leavitt J |title=Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain. |journal=Mol. Cell. Biol. |volume=10 |issue= 4 |pages= 1818–21 |year= 1990 |pmid= 2378651 |doi=
*cite journal | author=Lin CS, Aebersold RH, Kent SB, "et al." |title=Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts. |journal=Mol. Cell. Biol. |volume=8 |issue= 11 |pages= 4659–68 |year= 1989 |pmid= 3211125 |doi=
*cite journal | author=Matsushima K, Shiroo M, Kung HF, Copeland TD |title=Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1. |journal=Biochemistry |volume=27 |issue= 10 |pages= 3765–70 |year= 1988 |pmid= 3261603 |doi=
*cite journal | author=Kondo I, Shin K, Honmura S, "et al." |title=A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13. |journal=Hum. Genet. |volume=71 |issue= 3 |pages= 263–6 |year= 1986 |pmid= 3864729 |doi=
*cite journal | author=Arpin M, Friederich E, Algrain M, "et al." |title=Functional differences between L- and T-plastin isoforms. |journal=J. Cell Biol. |volume=127 |issue= 6 Pt 2 |pages= 1995–2008 |year= 1995 |pmid= 7806577 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Lin CS, Shen W, Chen ZP, "et al." |title=Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2457–67 |year= 1994 |pmid= 8139549 |doi=
*cite journal | author=Lin CS, Park T, Chen ZP, Leavitt J |title=Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2781–92 |year= 1993 |pmid= 8428952 |doi=
*cite journal | author=Lin CS, Chen ZP, Park T, "et al." |title=Characterization of the human L-plastin gene promoter in normal and neoplastic cells. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2793–801 |year= 1993 |pmid= 8428953 |doi=
*cite journal | author=Jones SL, Brown EJ |title=FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils. |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14623–30 |year= 1996 |pmid= 8663066 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Okumura Y, Yano M, Murakami M, "et al." |title=The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin. |journal=FEBS Lett. |volume=442 |issue= 1 |pages= 39–42 |year= 1999 |pmid= 9923600 |doi=
*cite journal | author=Wang J, Brown EJ |title=Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24349–56 |year= 1999 |pmid= 10446213 |doi=
*cite journal | author=Lin CS, Lau A, Yeh CC, "et al." |title=Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences. |journal=DNA Cell Biol. |volume=19 |issue= 1 |pages= 1–7 |year= 2000 |pmid= 10668786 |doi= 10.1089/104454900314654
*cite journal | author=Jia J, Han Q, Borregaard N, "et al." |title=Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. |journal=J. Mol. Biol. |volume=300 |issue= 5 |pages= 1271–81 |year= 2000 |pmid= 10903868 |doi= 10.1006/jmbi.2000.3925
*cite journal | author=Lollike K, Johnsen AH, Durussel I, "et al." |title=Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17762–9 |year= 2001 |pmid= 11279160 |doi= 10.1074/jbc.M100965200
*cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, "et al." |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Cancer research — This article is about research into cancer, in general. For the UK based charity, see Cancer Research UK. For the journal, see Cancer Research (journal). University of Florida Cancer Hospital Cancer research is basic research into cancer in order …   Wikipedia

  • EF hand — Pfam box Symbol = efhand Name = EF hand width = caption = Calmodulin with four EF Hand motifs. Pfam= PF00036 PROSITE=PDOC00018 InterPro= IPR002048 SMART= SCOP = 1osa TCDB = OPM family= OPM protein= 1djx PDB=PDB3|1s6jA:375 402 PDB3|1s6iA:375 403… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”