Homeostatic plasticity

Homeostatic plasticity

In Neuroscience, homeostatic plasticity refers to the capacity of neurons to regulate their own excitability relative to network activity, a compensatory adjustment that occurs over the timescale of days.

Homeostatic plasticity is thought to oppose Hebbian plasticity by modulating the activity of the synapse. Homeostatic plasticity was first discovered by Gina Turrigano, who published a paper in the journal Nature in 1998 describing a compensatory changes in miniature excitatory post-synaptic currents (mEPSCs) after chronic excitation or inhibition. The exact mechanisms underlying this mechanism are under active investigation.

The term homeostatic plasticity derives from two opposing concepts: ‘homeostatic’ (a product of the Greek words for ‘same’ and ‘state’ or ‘condition’) and plasticity (or 'change'), thus homeostatic plasticity means "staying the same through change."

References

* Turrigiano GG, Leslie KR, Desai NS, Rutherford LC and Nelson SB (1998), Activity-dependent scaling of quantal amplitude in neocortical neurons, Nature 391, 892-896 [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=9495341&itool=iconabstr&query_hl=20&itool=pubmed_docsum|Pub Med] .

* Turrigiano GG and Nelson SB (2004), Homeostatic Plasiticity in the Developing Nervous System, Nature Reviews Neuroscience 5, 97-107


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Developmental plasticity — is a general term referring to changes in neural connections during development as a result of environmental interactions as well as neural changes induced by learning. Much like neuroplasticity or brain plasticity, developmental plasticity is… …   Wikipedia

  • Synaptic plasticity — In neuroscience, synaptic plasticity is the ability of the connection, or synapse, between two neurons to change in strength. There are several underlying mechanisms that cooperate to achieve synaptic plasticity, including changes in the quantity …   Wikipedia

  • Metaplasticity — is a term originally coined by W.C. Abraham and M.F. Bear to refer to the plasticity of synaptic plasticity. Until that time synaptic plasticity had referred to the plastic nature of individual synapses. However this new form referred to the… …   Wikipedia

  • Dejerine-Roussy (Thalamic) Syndrome — Dejerine Roussy syndrome or thalamic pain syndrome is a condition developed after a thalamic stroke, a stroke causing damage to the thalamus. [1], [2]. This condition is not to be confused with Roussy Levy Syndrome , a genetic disorder [3], [4] …   Wikipedia

  • Clinical Neurochemistry — Progression of Huntington s Diesase. A microscope image of Medium spiny neurons (yellow) with nuclear inclusions (orange), which occur as part of the disease process. Clinical Neurochemistry is the field of neurological biochemistry which relates …   Wikipedia

  • Sleep — Waking up redirects here. For other uses, see Waking Up (disambiguation). This article is about sleep in general; for specifically non human sleep see Sleep (non human); for other uses, see Sleep (disambiguation). Sleeping child Sleep is a… …   Wikipedia

  • Alzheimer's disease — Alzheimer redirects here. For other uses, see Alzheimer (disambiguation). Alzheimer s disease Classification and external resources …   Wikipedia

  • nervous system — Anat., Zool. 1. the system of nerves and nerve centers in an animal or human, including the brain, spinal cord, nerves, and ganglia. 2. a particular part of this system. Cf. autonomic nervous system, central nervous system, peripheral nervous… …   Universalium

  • Glutamic acid — Glutamic acid …   Wikipedia

  • Hypothalamus — Brain: Hypothalamus Location of the human hypothalamus …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”