Developmental plasticity

Developmental plasticity is a general term referring to changes in neural connections during development as a result of environmental interactions as well as neural changes induced by learning. Much like neuroplasticity or brain plasticity, developmental plasticity is specific to the change in neurons and synaptic connections as a consequence of developmental processes.

Mechanisms

During development, the central nervous system acquires information via endogenous or exogenous factors as well as learning experiences. In acquiring and storing such information, the plastic nature of the central nervous system allows for the adaptation of existing neural connections in order to accommodate new information and experiences, resulting in developmental plasticity. This form of plasticity that occurs during development is the result of three predominant mechanisms: synaptic and homeostatic plasticity, and learning.

Synaptic plasticity

The underlying principle of synaptic plasticity is that synapses undergo and activity-dependent and selective strengthening or weakening so new information can be stored^[1]. Synaptic plasticity depends on numerous factors including the threshold of the presynaptic stimulus in addition to the relative concentrations of neurotransmitter molecules. Synaptic plasticity has long been implicated for its role in memory storage and is thought to play a key role in learning^[2]. However, during developmental periods synaptic plasticity is of particular importance as changes in the network of synaptic connections can ultimately lead to changes in developmental milestones. For instance, the initial overproduction of synapses during development is key to plasticity that occurs in the visual and auditory cortex. In experiments conducted by Hubel and Wiesel, the visual cortex of kittens exhibits synaptic plasticity in the refinement neural connections following visual inputs. Correspondingly, in the absence of such inputs during development, the visual field fails to develop properly and can lead to abnormal structures and behavior^[3]. Furthermore, research suggests that this initial overproduction of synapses during developmental periods provides the foundation by which many synaptic connections can be formed, thus resulting in more synaptic plasticity. In the same way that synapses are abundant during development, there are also refining mechanisms that coincidently refine the connectivity of neural circuits. This regulatory process allows the strengthening of important or frequently used synaptic connections while reducing the amount of weak connections.

Homeostatic plasticity

In order to maintain balance, homeostatic controls exist to regulate the overall activity of neural circuits specifically by regulating the destabilizing effects of developmental and learning processes that result in changes of synaptic strength. Homeostatic plasticity also helps regulate prolonged excitatory responses, which can lead to a reduction in all of a neuron’s synaptic responses^[4]. While the exact mechanisms by which homeostatic plasticity acts remains unclear, recent studies raise the idea that homeostatic plasticity is modulated according to the period of development or challenges in existing neural circuits^[5].

Learning

While synaptic plasticity is considered to be a by-product of learning, learning requires interaction with the environment to acquire the new information or behavior, whereas synaptic plasticity merely represents the change in strength or configuration of neural circuits. Learning is of crucial importance postnatally as there is considerable interaction with the environment and the potential for acquiring new information is greatest. By depending largely upon selective experiences, neural connections are altered and strengthened in a manner that is unique to those experiences. Experimentally this can be seen when rats are raised in an environment that allows ample social interaction, resulting in increased brain weight and cortical thickness^[6]. In contrast, the adverse is seen following rearing in an environment devoid of interaction. Also, learning plays a sizeable role in the selective acquisition of information and is markedly demonstrated as children develop one language as opposed to another. Another example of such experience dependent plasticity that is critical during development is the occurrence of imprinting. This occurs as a result of the young child or animal experiencing a novel stimuli and rapidly learning the behavior in response.

Neural Development

The formation of the nervous system is one of the most crucial events in the developing embryo. Specifically, the differentiation of stem cell precursors into specialized neurons gives rise to the formation of synapses and neural circuits, which is key to the principle of plasticity. During this pivotal point in development, consequent developmental processes like the differentiation and specialization of neurons are highly sensitive to exogenous and endogenous factors. For example, in utero exposure to nicotine has been linked to adverse effects such as severe physical and cognitive deficits as a result of impeding the normal activation of acetylcholine receptors. In a recent study, the connection between such nicotine exposure and prenatal development was assessed. It was determined that nicotine exposure in early development can have a lasting and encompassing effect on neuronal structures, underlying the behavioral and cognitive defects observed in exposed humans and animals. Additionally, by disrupting proper synaptic function through nicotine exposure, the overall circuit may become less sensitive and responsive to stimuli, resulting in compensatory developmental plasticity^[7]. It is for this reason that exposure to various environmental factors during developmental periods can cause profound effects on subsequent neural functioning.

Critical Period

The concept of critical periods is a widely accepted and prominent theme in development, with strong implications to developmental plasticity. Critical periods establish a time frame in which the shaping of neural networks can be carried out. During these critical periods in development, plasticity occurs as a result of changes in the structure or function of developing neural circuits. Such critical periods can also be experience-dependent, in the instance of learning via new experiences. Or can be independent of the environmental experience and be dependent on biological mechanisms including endogenous or exogenous factors. Again, one of the most pervading examples of this can be seen in the development of the visual cortex in addition to the acquisition of language as a result of developmental plasticity during the critical period. A lesser known example, however, remains the critical development of respiratory control during developmental periods. At birth, the development of respiratory control neural circuits is incomplete, requiring complex inetractions from both the environment and internal factors. Experimentally exposing two week-old kittens and rats to hyperoxic conditions, completely eliminates the carotid chemoreceptor response to hypoxia, and consequently resulting in respiratory impairment^[8]. This has dramatic clinical significance as newborn infants are often supplemented with considerable amounts of oxygen, which could detrimentally affect the way in which neural circuits for respiratory control develop during the critical period. Additionally, when stimuli or experiences are elicited outside of the critical period, usually the results have little to no lasting effect, which could also lead to severe developmental impairment.

Spontaneous Network Activity

Another lesser known element of developmental plasticity includes spontaneous bursts of action potentials in developing neural circuits, also referred to as spontaneous network activity. During the early development of neural connections, excitatory synapses undergo spontaneous activation, resulting in elevated intracellular calcium levels which signals the onset of innumerable signaling cascades and developmental processes. As an example, prior to birth neural circuits in the retina undergo spontaneous network activity, which has been found to elicit the formation of retinogeniculate connections^[9]. Examples of spontaneous network activity during development are also exhibited in the proper formation of neuromuscular circuits^[10]. It is believed that spontaneous network activity establishes a scaffold for subsequent learning and information acquisition following the initial establishment of synaptic connections during development.

See also

• Hebbian theory
• Long-term potentiation
• Long-term depression
• NMDA receptor
• GABA receptor
• Cultured neuronal network

Footnotes

1. ^ Foehring RC, Lorenzon NM. Neuromodulation, Development and Synaptic Plasticity. Canadian Journal of Experimental Psychology 1999; 53:45-61.
2. ^ Black JE. How A Child Builds Its Brain: Some Lessons from Animal Studies and Neural Plasticity. Preventative Medicine 1998; 27:168-171.
3. ^ Synaptic Plasticity: Molecular, Cellular, and Functional Aspects. Michel Baudry, Richard F. Thompson, Joel L. Davis. The Quarterly Review of Biology.
4. ^ Butz M, Worgotter F, van Ooyen A. Activity-dependent Structural Plasticity. Brain Research Reviews 2009; 60:287-305.
5. ^ Corette J. Wierenga, Michael F. Walsh, and Gina G. Turrigiano Temporal Regulation of the Expression Locus of Homeostatic Plasticity Journal of Neurophysiology 2006; 96: 2127-2133.
6. ^ Bennett EL, Diamond MC, Krech D, Rosenzweig MR. Chang F-LF, Greenough WT. Lateralized effects of monocular and anatomical plasticity of brain. Science 1964;146:610–619.
7. ^ Heath, C. J., & Picciotto, M. R.. Nicotine-induced plasticity during development: Modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. Neuropharmacology 2009; 56:254-262.
8. ^ Carroll, JL. Plasticity in Respiratory Motor Control, Invited Review: Developmental plasticity in respiratory control. Journal of Applied Physiology 2003; 94:375-389.
9. ^ Feller M. Spontaneous Correlated Activity in Developing Neural Circuits. Neuron 1999; 22:653-656.
10. ^ Gonzalez-Islas C, Wenner P. Spontaneous Network Activity in the Embryonic Spinal Cord Regulates AMPAergic and GABAergic Synaptic Strength. Neuron 2006; 49:563-575.

References

• Corette J. Wierenga, Michael F. Walsh, and Gina G. Turrigiano Temporal Regulation of the Expression Locus of Homeostatic Plasticity Journal of Neurophysiology 2006; 96: 2127-2133.
• Heath, C. J., & Picciotto, M. R.. Nicotine-induced plasticity during development: Modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. Neuropharmacology 2009; 56:254-262
• Synaptic Plasticity: Molecular, Cellular, and Functional Aspects. Michel Baudry, Richard F. Thompson, Joel L. Davis. The Quarterly Review of Biology
• Bennett EL, Diamond MC, Krech D, Rosenzweig MR. Chang F-LF, Greenough WT. Lateralized effects of monocular and anatomical plasticity of brain. Science 1964;146:610–619.
• Black JE. How A Child Builds Its Brain: Some Lessons from Animal Studies and Neural Plasticity. Preventative Medicine 1998; 27:168-171.
• Foehring RC, Lorenzon NM. Neuromodulation, Development and Synaptic Plasticity. Canadian Journal of Experimental Psychology 1999; 53:45-61.
• Carroll, JL. Plasticity in Respiratory Motor Control, Invited Review: Developmental plasticity in respiratory control. Journal of Applied Physiology 2003; 94:375-389.
• Butz M, Worgotter F, van Ooyen A. Activity-dependent Structural Plasticity. Brain Research Reviews 2009; 60:287-305.
• Feller M. Spontaneous Correlated Activity in Developing Neural Circuits. Neuron 1999; 22:653-656.
• Gonzalez-Islas C, Wenner P. Spontaneous Network Activity in the Embryonic Spinal Cord Regulates AMPAergic and GABAergic Synaptic Strength. Neuron 2006; 49:563-575.