- Aorticopulmonary septum
Infobox Embryology
Name = PAGENAME
Latin =
GraySubject = 135
GrayPage = 514
Caption = Diagrams to show the development of the septum of the aortic bulb and of the ventricles.
Caption2 = Transverse sections through the aortic bulb to show the growth of the aortic septum. The lowest section is on the left, the highest on the right of the figure.
System =
CarnegieStage =
Days = 37
Precursor =neural crest
GivesRiseTo =
MeshName =
MeshNumber =
DorlandsPre =
DorlandsSuf =
The aorticopulmonary septum (also called the spiral septum, or aortic septum in older texts) is developmentally formed fromneural crest , specifically the cardiacneural crest, and actively separates theaorta and pulmonary arteries and fuses with theinterventricular septum within theheart during development. [cite journal | author = Kirby ML, Gale TF, and Stewart DE. | title = Neural crest cells contribute to normal aorticopulmonary septation. | journal = Science | volume = 220 | issue =4061 | pages = 1059–61 | year =1983 | pmid = 6844926 | doi = 10.1126/science.6844926] [cite journal | author = Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM..| title = Fate of the mammalian cardiac neural crest...journal = Development. | volume = 127| issue =8| pages = 1607–16 | year =2000 | pmid = 10725237]The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from
contractile , hemodynamic, andextracellular matrix interactions.Clinical significance
The development of the aorticopulmonary septum is complex, and disorders of development are associated with several congenital heart defects, including:
*
persistent truncus arteriosus [cite web |url=http://library.med.utah.edu/WebPath/CVHTML/CV103.html |title=Cardiovascular Pathology |accessdate=2007-10-14 |format= |work=]
*double outlet right ventricle
*transposition of the great vessels
*tetralogy of Fallot References
External links
* http://isc.temple.edu/marino/embryology/Heart98/abnorm_text.htm
Wikimedia Foundation. 2010.