CAS number 137219-37-5 YesY
ChemSpider 26001665 YesY
Jmol-3D images Image 1
Molecular formula C57H87N7O15
Molar mass 1110.34 g mol−1
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Aplidine, also known as dihydrodidemnin B, is a chemical compound extracted from the ascidian Aplidium albicans.[1] It is currently undergoing clinical trial testing. It is a member of the class of compounds known as didemnins.

Chemical structure

Aplidine is a cyclic depsipeptide, meaning it is a cyclic peptide in which there is one or more ester bond in place of one or more of a peptide bond. Its chemical structure is very close to that of didemnin B, the only difference being that the lactate residue in didemnin B is present in the oxidized pyruvate version.

Pharmacological activity

Like all didemnin compounds, it exhibits antitumor, antiviral and immunosuppressive activities. It shows promise in shrinking tumors in pancreatic, stomach, bladder, and prostate cancers.[2][3] As of 2007, it was undergoing multicenter phase II clinical trials.[3] In July 2003, aplidine was granted orphan drug status by the European Medicines Agency for treating acute lymphoblastic leukemia.[4]


  1. ^ Cragg, G.M. and Newman, D.J. (2004). Journal of Natural Products 67 (8): 1216–1238. doi:10.1021/np040031y. PMID 15332835. 
  2. ^ Garrison, Tom. Oceanography: An Invitation to Marine Science 4th ed. United States: Brooks/Cole. 2002. 98.
  3. ^ a b Adrio, J. et al (2007). "Total Synthesis and Biological Evaluation of Tamandarin B Analogues". Journal of Organic Chemistry 72 (14): 5129–5138. 
  4. ^ Public Summary of Positive Opinion for Orphan Designation of Aplidine for the Treatment of Acute Lymphoblastic Leukaemia

Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • aplidine — A substance that is being studied in the treatment of cancer. It is obtained from a marine organism …   English dictionary of cancer terms

  • Didemnin — Structure of Didemnins A C Didemnins are cyclic depsipeptide compounds isolated from a tunicate (sea squirt) of the genus Trididemnum (family of Didemnidæ) that were collected in the Caribbean Sea. They were first isolated in 1978 at the… …   Wikipedia

  • Tunicate — Temporal range: Cambrian stage 3–Recent …   Wikipedia

  • List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”